Influence of the nature of quantum dot surface cations on interactions with DNA

Rahina Mahtab, Sheldon M. Sealey, Simona Elisabeta Murph, Brian Kinard, Tyler Ray, Catherine J. Murphy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Quantum dots are semiconductor nanoparticles that are ∼1-10 nm in diameter, similar to small proteins, and their photoluminescence is sensitive to the presence and nature of adsorbates. We have deployed these nanomaterials as luminescent probes of DNA structure. Sequence dependent conformational flexibility of DNA is of great interest due to its implications for drug-DNA and DNA-protein interactions. The counterion atmosphere surrounding DNA plays an important role in its structure, dynamics, and packaging. In this paper, we investigate the effect that various monovalent and divalent cations have on the binding of 4.5 nm CdS quantum dots to oligonucleotides that have sequence-directed intrinsic structure.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume101
Issue number4
DOIs
StatePublished - Apr 1 2007

Fingerprint

Quantum Dots
Semiconductor quantum dots
Cations
DNA
Monovalent Cations
Nanostructures
Divalent Cations
DNA Probes
Product Packaging
Adsorbates
Atmosphere
Nanostructured materials
Oligonucleotides
Packaging
Photoluminescence
Proteins
Nanoparticles
Pharmaceutical Preparations

Keywords

  • CdS
  • DNA
  • Nanoparticle
  • Oligonucleotides
  • Photoluminescence
  • Quantum dots

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Mahtab, R., Sealey, S. M., Murph, S. E., Kinard, B., Ray, T., & Murphy, C. J. (2007). Influence of the nature of quantum dot surface cations on interactions with DNA. Journal of Inorganic Biochemistry, 101(4), 559-564. https://doi.org/10.1016/j.jinorgbio.2006.11.019

Influence of the nature of quantum dot surface cations on interactions with DNA. / Mahtab, Rahina; Sealey, Sheldon M.; Murph, Simona Elisabeta; Kinard, Brian; Ray, Tyler; Murphy, Catherine J.

In: Journal of Inorganic Biochemistry, Vol. 101, No. 4, 01.04.2007, p. 559-564.

Research output: Contribution to journalArticle

Mahtab, R, Sealey, SM, Murph, SE, Kinard, B, Ray, T & Murphy, CJ 2007, 'Influence of the nature of quantum dot surface cations on interactions with DNA', Journal of Inorganic Biochemistry, vol. 101, no. 4, pp. 559-564. https://doi.org/10.1016/j.jinorgbio.2006.11.019
Mahtab, Rahina ; Sealey, Sheldon M. ; Murph, Simona Elisabeta ; Kinard, Brian ; Ray, Tyler ; Murphy, Catherine J. / Influence of the nature of quantum dot surface cations on interactions with DNA. In: Journal of Inorganic Biochemistry. 2007 ; Vol. 101, No. 4. pp. 559-564.
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