Inhibition of Pyrimidine Dimer Formation in DNA by Cationic Molecules: Role of Energy Transfer

B. M. Sutherland, John C. Sutherland

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In addition to the acridine dyes, acridine orange and proflavine, we find that three other cationic molecules which bind to DNA—ethidium bromide, chloroquine, and methyl green—inhibit the production of cyclobutyl pyrimidine dimers by ultraviolet radiation. Intercalation is not necessary for dimer inhibition. The long range nature of the inhibition implies that energy transfer is responsible. The transfer is between the lowest excited singlet state of DNA and the acceptor singlet, and seems to involve the Förster mechanism.

Original languageEnglish (US)
Pages (from-to)1045-1055
Number of pages11
JournalBiophysical Journal
Volume9
Issue number8
DOIs
StatePublished - Jan 1 1969

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methyl bromide
Proflavine
Acridines
Pyrimidine Dimers
Acridine Orange
Energy Transfer
Chloroquine
Coloring Agents
Radiation
DNA

ASJC Scopus subject areas

  • Biophysics

Cite this

Inhibition of Pyrimidine Dimer Formation in DNA by Cationic Molecules : Role of Energy Transfer. / Sutherland, B. M.; Sutherland, John C.

In: Biophysical Journal, Vol. 9, No. 8, 01.01.1969, p. 1045-1055.

Research output: Contribution to journalArticle

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