Abstract
In addition to the acridine dyes, acridine orange and proflavine, we find that three other cationic molecules which bind to DNA—ethidium bromide, chloroquine, and methyl green—inhibit the production of cyclobutyl pyrimidine dimers by ultraviolet radiation. Intercalation is not necessary for dimer inhibition. The long range nature of the inhibition implies that energy transfer is responsible. The transfer is between the lowest excited singlet state of DNA and the acceptor singlet, and seems to involve the Förster mechanism.
Original language | English (US) |
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Pages (from-to) | 1045-1055 |
Number of pages | 11 |
Journal | Biophysical Journal |
Volume | 9 |
Issue number | 8 |
DOIs | |
State | Published - 1969 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics