Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus

Fernando Ovalle, Ricardo Azziz

Research output: Contribution to journalReview article

279 Citations (Scopus)

Abstract

Objective: To review the definition and prevalence of two insulin resistance (IR)-associated phenotypes, polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, as well as the risk and nature of their simultaneous presentation. Design: Review of published literature. Result(s): Insulin resistance affects between 10% and 25% of the general population. Two common disorders frequently associated with IR are PCOS, affecting 4% to 6% of reproductive-aged women, and type 2 diabetes mellitus, which is observed in about 2% to 6% of similarly aged women. Overall, about 50% to 70% of women with PCOS and 80% to 100% of patients with type 2 diabetes mellitus have variable degrees of IR. Insulin resistance and its secondary hyperinsulinemia appear to underlie many of the endocrine features of PCOS in a large proportion of such patients. The risk of type 2 diabetes mellitus among PCOS patients is 5- to 10-fold higher than normal. In turn, the risk of PCOS among reproductive-aged type 2 diabetes mellitus patients appears to be similarly increased. Conclusion(s): It remains to be determined whether PCOS and type 2 diabetes mellitus represent no more than different clinical manifestations of the same IR syndrome, with their phenotypic differences due to the presence or absence of a coincidental genetic defect at the level of the ovary or pancreas, respectively, or representing the result of etiologically different subtypes of IR syndromes.

Original languageEnglish (US)
Pages (from-to)1095-1105
Number of pages11
JournalFertility and Sterility
Volume77
Issue number6
DOIs
StatePublished - Jan 1 2002

Fingerprint

Polycystic Ovary Syndrome
Type 2 Diabetes Mellitus
Insulin Resistance
Hyperinsulinism
Pancreas
Ovary
Phenotype
Population

Keywords

  • Androgen excess
  • Diabetes
  • Glucose intolerance
  • Insulin resistance
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. / Ovalle, Fernando; Azziz, Ricardo.

In: Fertility and Sterility, Vol. 77, No. 6, 01.01.2002, p. 1095-1105.

Research output: Contribution to journalReview article

Ovalle, Fernando ; Azziz, Ricardo. / Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. In: Fertility and Sterility. 2002 ; Vol. 77, No. 6. pp. 1095-1105.
@article{d33da15ac7694622b8a134bd44e0c307,
title = "Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus",
abstract = "Objective: To review the definition and prevalence of two insulin resistance (IR)-associated phenotypes, polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, as well as the risk and nature of their simultaneous presentation. Design: Review of published literature. Result(s): Insulin resistance affects between 10{\%} and 25{\%} of the general population. Two common disorders frequently associated with IR are PCOS, affecting 4{\%} to 6{\%} of reproductive-aged women, and type 2 diabetes mellitus, which is observed in about 2{\%} to 6{\%} of similarly aged women. Overall, about 50{\%} to 70{\%} of women with PCOS and 80{\%} to 100{\%} of patients with type 2 diabetes mellitus have variable degrees of IR. Insulin resistance and its secondary hyperinsulinemia appear to underlie many of the endocrine features of PCOS in a large proportion of such patients. The risk of type 2 diabetes mellitus among PCOS patients is 5- to 10-fold higher than normal. In turn, the risk of PCOS among reproductive-aged type 2 diabetes mellitus patients appears to be similarly increased. Conclusion(s): It remains to be determined whether PCOS and type 2 diabetes mellitus represent no more than different clinical manifestations of the same IR syndrome, with their phenotypic differences due to the presence or absence of a coincidental genetic defect at the level of the ovary or pancreas, respectively, or representing the result of etiologically different subtypes of IR syndromes.",
keywords = "Androgen excess, Diabetes, Glucose intolerance, Insulin resistance, Polycystic ovary syndrome",
author = "Fernando Ovalle and Ricardo Azziz",
year = "2002",
month = "1",
day = "1",
doi = "10.1016/S0015-0282(02)03111-4",
language = "English (US)",
volume = "77",
pages = "1095--1105",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus

AU - Ovalle, Fernando

AU - Azziz, Ricardo

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Objective: To review the definition and prevalence of two insulin resistance (IR)-associated phenotypes, polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, as well as the risk and nature of their simultaneous presentation. Design: Review of published literature. Result(s): Insulin resistance affects between 10% and 25% of the general population. Two common disorders frequently associated with IR are PCOS, affecting 4% to 6% of reproductive-aged women, and type 2 diabetes mellitus, which is observed in about 2% to 6% of similarly aged women. Overall, about 50% to 70% of women with PCOS and 80% to 100% of patients with type 2 diabetes mellitus have variable degrees of IR. Insulin resistance and its secondary hyperinsulinemia appear to underlie many of the endocrine features of PCOS in a large proportion of such patients. The risk of type 2 diabetes mellitus among PCOS patients is 5- to 10-fold higher than normal. In turn, the risk of PCOS among reproductive-aged type 2 diabetes mellitus patients appears to be similarly increased. Conclusion(s): It remains to be determined whether PCOS and type 2 diabetes mellitus represent no more than different clinical manifestations of the same IR syndrome, with their phenotypic differences due to the presence or absence of a coincidental genetic defect at the level of the ovary or pancreas, respectively, or representing the result of etiologically different subtypes of IR syndromes.

AB - Objective: To review the definition and prevalence of two insulin resistance (IR)-associated phenotypes, polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, as well as the risk and nature of their simultaneous presentation. Design: Review of published literature. Result(s): Insulin resistance affects between 10% and 25% of the general population. Two common disorders frequently associated with IR are PCOS, affecting 4% to 6% of reproductive-aged women, and type 2 diabetes mellitus, which is observed in about 2% to 6% of similarly aged women. Overall, about 50% to 70% of women with PCOS and 80% to 100% of patients with type 2 diabetes mellitus have variable degrees of IR. Insulin resistance and its secondary hyperinsulinemia appear to underlie many of the endocrine features of PCOS in a large proportion of such patients. The risk of type 2 diabetes mellitus among PCOS patients is 5- to 10-fold higher than normal. In turn, the risk of PCOS among reproductive-aged type 2 diabetes mellitus patients appears to be similarly increased. Conclusion(s): It remains to be determined whether PCOS and type 2 diabetes mellitus represent no more than different clinical manifestations of the same IR syndrome, with their phenotypic differences due to the presence or absence of a coincidental genetic defect at the level of the ovary or pancreas, respectively, or representing the result of etiologically different subtypes of IR syndromes.

KW - Androgen excess

KW - Diabetes

KW - Glucose intolerance

KW - Insulin resistance

KW - Polycystic ovary syndrome

UR - http://www.scopus.com/inward/record.url?scp=0036283724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036283724&partnerID=8YFLogxK

U2 - 10.1016/S0015-0282(02)03111-4

DO - 10.1016/S0015-0282(02)03111-4

M3 - Review article

VL - 77

SP - 1095

EP - 1105

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 6

ER -