International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study

Kallol Ray Chaudhuri, Pablo Martinez-Martin, Anthony H.V. Schapira, Fabrizio Stocchi, Kapil Dev Sethi, Per Odin, Richard G. Brown, William Koller, Paolo Barone, Graeme MacPhee, Linda Kelly, Martin Rabey, Doug MacMahon, Sue Thomas, William Ondo, David Rye, Alison Forbes, Susanne Tluk, Vandana Dhawan, Annette BowronAdrian J. Williams, Charles W. Olanow

Research output: Contribution to journalArticle

561 Citations (Scopus)

Abstract

Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.

Original languageEnglish (US)
Pages (from-to)916-923
Number of pages8
JournalMovement Disorders
Volume21
Issue number7
DOIs
StatePublished - Jan 1 2006

Fingerprint

Multicenter Studies
Parkinson Disease
Patient Advocacy
Apathy
Secondary Care
Diplopia
Smell
Surveys and Questionnaires
Referral and Consultation
Health

Keywords

  • Nonmotor
  • Parkinson's disease
  • Quality of life
  • Questionnaire
  • Unified Parkinson's Disease Rating Scale

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Chaudhuri, K. R., Martinez-Martin, P., Schapira, A. H. V., Stocchi, F., Sethi, K. D., Odin, P., ... Olanow, C. W. (2006). International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study. Movement Disorders, 21(7), 916-923. https://doi.org/10.1002/mds.20844

International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study. / Chaudhuri, Kallol Ray; Martinez-Martin, Pablo; Schapira, Anthony H.V.; Stocchi, Fabrizio; Sethi, Kapil Dev; Odin, Per; Brown, Richard G.; Koller, William; Barone, Paolo; MacPhee, Graeme; Kelly, Linda; Rabey, Martin; MacMahon, Doug; Thomas, Sue; Ondo, William; Rye, David; Forbes, Alison; Tluk, Susanne; Dhawan, Vandana; Bowron, Annette; Williams, Adrian J.; Olanow, Charles W.

In: Movement Disorders, Vol. 21, No. 7, 01.01.2006, p. 916-923.

Research output: Contribution to journalArticle

Chaudhuri, KR, Martinez-Martin, P, Schapira, AHV, Stocchi, F, Sethi, KD, Odin, P, Brown, RG, Koller, W, Barone, P, MacPhee, G, Kelly, L, Rabey, M, MacMahon, D, Thomas, S, Ondo, W, Rye, D, Forbes, A, Tluk, S, Dhawan, V, Bowron, A, Williams, AJ & Olanow, CW 2006, 'International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study', Movement Disorders, vol. 21, no. 7, pp. 916-923. https://doi.org/10.1002/mds.20844
Chaudhuri, Kallol Ray ; Martinez-Martin, Pablo ; Schapira, Anthony H.V. ; Stocchi, Fabrizio ; Sethi, Kapil Dev ; Odin, Per ; Brown, Richard G. ; Koller, William ; Barone, Paolo ; MacPhee, Graeme ; Kelly, Linda ; Rabey, Martin ; MacMahon, Doug ; Thomas, Sue ; Ondo, William ; Rye, David ; Forbes, Alison ; Tluk, Susanne ; Dhawan, Vandana ; Bowron, Annette ; Williams, Adrian J. ; Olanow, Charles W. / International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study. In: Movement Disorders. 2006 ; Vol. 21, No. 7. pp. 916-923.
@article{e07f474822f94a1d8d1783c043d6a7a7,
title = "International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study",
abstract = "Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.",
keywords = "Nonmotor, Parkinson's disease, Quality of life, Questionnaire, Unified Parkinson's Disease Rating Scale",
author = "Chaudhuri, {Kallol Ray} and Pablo Martinez-Martin and Schapira, {Anthony H.V.} and Fabrizio Stocchi and Sethi, {Kapil Dev} and Per Odin and Brown, {Richard G.} and William Koller and Paolo Barone and Graeme MacPhee and Linda Kelly and Martin Rabey and Doug MacMahon and Sue Thomas and William Ondo and David Rye and Alison Forbes and Susanne Tluk and Vandana Dhawan and Annette Bowron and Williams, {Adrian J.} and Olanow, {Charles W.}",
year = "2006",
month = "1",
day = "1",
doi = "10.1002/mds.20844",
language = "English (US)",
volume = "21",
pages = "916--923",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease

T2 - The NMSQuest study

AU - Chaudhuri, Kallol Ray

AU - Martinez-Martin, Pablo

AU - Schapira, Anthony H.V.

AU - Stocchi, Fabrizio

AU - Sethi, Kapil Dev

AU - Odin, Per

AU - Brown, Richard G.

AU - Koller, William

AU - Barone, Paolo

AU - MacPhee, Graeme

AU - Kelly, Linda

AU - Rabey, Martin

AU - MacMahon, Doug

AU - Thomas, Sue

AU - Ondo, William

AU - Rye, David

AU - Forbes, Alison

AU - Tluk, Susanne

AU - Dhawan, Vandana

AU - Bowron, Annette

AU - Williams, Adrian J.

AU - Olanow, Charles W.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.

AB - Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.

KW - Nonmotor

KW - Parkinson's disease

KW - Quality of life

KW - Questionnaire

KW - Unified Parkinson's Disease Rating Scale

UR - http://www.scopus.com/inward/record.url?scp=33746889002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746889002&partnerID=8YFLogxK

U2 - 10.1002/mds.20844

DO - 10.1002/mds.20844

M3 - Article

C2 - 16547944

AN - SCOPUS:33746889002

VL - 21

SP - 916

EP - 923

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 7

ER -