International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease

P. Martinez-Martin, C. Rodriguez-Blazquez, K. Abe, K. B. Bhattacharyya, B. R. Bloem, F. J. Carod-Artal, R. Prakash, R. A.J. Esselink, C. Falup-Pecurariu, M. Gallardo, P. Mir, Y. Naidu, A. Nicoletti, Kapil Dev Sethi, Y. Tsuboi, J. J. Van Hilten, M. Visser, M. Zappia, K. R. Chaudhuri

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study. METHODS: Data were collected in 12 centers across 10 countries in America, Asia, and Europe. In addition to the NMSS, the following measures were applied: Scales for Outcomes in Parkinson's Disease (SCOPA)-Motor, SCOPA-Psychiatric Complications (SCOPA-PC), SCOPA-Cognition, Hoehn and Yahr Staging (HY), Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD), SCOPA-Autonomic, Parkinson's Disease Sleep Scale (PDSS), Parkinson's Disease Questionnaire-39 items (PDQ-39), and EuroQol-5 dimensions (EQ-5D). NMSS acceptability, reliability, validity, and precision were analyzed. RESULTS: Four hundred eleven patients with PD, 61.3% men, were recruited. The mean age was 64.5 ± 9.9 years, and mean disease duration was 8.1 ± 5.7 years. The NMSS score was 57.1 ± 44.0 points. The scale was free of floor or ceiling effects. For domains, the Cronbach α coefficient ranged from 0.44 to 0.85. The intraclass correlation coefficient (0.90 for the total score, 0.67-0.91 for domains) and Lin concordance coefficient (0.88) suggested satisfactory reproducibility. The NMSS total score correlated significantly with SCOPA-Autonomic, PDQ-39, and EQ-5D (rS = 0.57-0.70). Association was close between NMSS domains and the corresponding SCOPA-Autonomic domains (rS = 0.51-0.65) and also with scales measuring related constructs (PDSS, SCOPA-PC) (all p < 0.0001). The NMSS total score was higher for women (p < 0.02) and for increasing disease duration, HY, and CISI-PD severity level (p < 0.001). The SEM was 13.91 for total score and 1.71 to 4.73 for domains. CONCLUSION: The Non-Motor Symptoms Scale is an acceptable, reproducible, valid, and precise assessment instrument for nonmotor symptoms in Parkinson disease.

Original languageEnglish (US)
Pages (from-to)1584-1591
Number of pages8
JournalNeurology
Volume73
Issue number19
DOIs
StatePublished - Jan 1 2009

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Psychometrics
Parkinson Disease
Autonomic Nervous System Diseases
Sleep
Symptom Assessment
Reproducibility of Results
Cognition
Psychiatry

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Martinez-Martin, P., Rodriguez-Blazquez, C., Abe, K., Bhattacharyya, K. B., Bloem, B. R., Carod-Artal, F. J., ... Chaudhuri, K. R. (2009). International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease. Neurology, 73(19), 1584-1591. https://doi.org/10.1212/WNL.0b013e3181c0d416

International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease. / Martinez-Martin, P.; Rodriguez-Blazquez, C.; Abe, K.; Bhattacharyya, K. B.; Bloem, B. R.; Carod-Artal, F. J.; Prakash, R.; Esselink, R. A.J.; Falup-Pecurariu, C.; Gallardo, M.; Mir, P.; Naidu, Y.; Nicoletti, A.; Sethi, Kapil Dev; Tsuboi, Y.; Van Hilten, J. J.; Visser, M.; Zappia, M.; Chaudhuri, K. R.

In: Neurology, Vol. 73, No. 19, 01.01.2009, p. 1584-1591.

Research output: Contribution to journalArticle

Martinez-Martin, P, Rodriguez-Blazquez, C, Abe, K, Bhattacharyya, KB, Bloem, BR, Carod-Artal, FJ, Prakash, R, Esselink, RAJ, Falup-Pecurariu, C, Gallardo, M, Mir, P, Naidu, Y, Nicoletti, A, Sethi, KD, Tsuboi, Y, Van Hilten, JJ, Visser, M, Zappia, M & Chaudhuri, KR 2009, 'International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease', Neurology, vol. 73, no. 19, pp. 1584-1591. https://doi.org/10.1212/WNL.0b013e3181c0d416
Martinez-Martin P, Rodriguez-Blazquez C, Abe K, Bhattacharyya KB, Bloem BR, Carod-Artal FJ et al. International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease. Neurology. 2009 Jan 1;73(19):1584-1591. https://doi.org/10.1212/WNL.0b013e3181c0d416
Martinez-Martin, P. ; Rodriguez-Blazquez, C. ; Abe, K. ; Bhattacharyya, K. B. ; Bloem, B. R. ; Carod-Artal, F. J. ; Prakash, R. ; Esselink, R. A.J. ; Falup-Pecurariu, C. ; Gallardo, M. ; Mir, P. ; Naidu, Y. ; Nicoletti, A. ; Sethi, Kapil Dev ; Tsuboi, Y. ; Van Hilten, J. J. ; Visser, M. ; Zappia, M. ; Chaudhuri, K. R. / International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease. In: Neurology. 2009 ; Vol. 73, No. 19. pp. 1584-1591.
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abstract = "BACKGROUND: Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study. METHODS: Data were collected in 12 centers across 10 countries in America, Asia, and Europe. In addition to the NMSS, the following measures were applied: Scales for Outcomes in Parkinson's Disease (SCOPA)-Motor, SCOPA-Psychiatric Complications (SCOPA-PC), SCOPA-Cognition, Hoehn and Yahr Staging (HY), Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD), SCOPA-Autonomic, Parkinson's Disease Sleep Scale (PDSS), Parkinson's Disease Questionnaire-39 items (PDQ-39), and EuroQol-5 dimensions (EQ-5D). NMSS acceptability, reliability, validity, and precision were analyzed. RESULTS: Four hundred eleven patients with PD, 61.3{\%} men, were recruited. The mean age was 64.5 ± 9.9 years, and mean disease duration was 8.1 ± 5.7 years. The NMSS score was 57.1 ± 44.0 points. The scale was free of floor or ceiling effects. For domains, the Cronbach α coefficient ranged from 0.44 to 0.85. The intraclass correlation coefficient (0.90 for the total score, 0.67-0.91 for domains) and Lin concordance coefficient (0.88) suggested satisfactory reproducibility. The NMSS total score correlated significantly with SCOPA-Autonomic, PDQ-39, and EQ-5D (rS = 0.57-0.70). Association was close between NMSS domains and the corresponding SCOPA-Autonomic domains (rS = 0.51-0.65) and also with scales measuring related constructs (PDSS, SCOPA-PC) (all p < 0.0001). The NMSS total score was higher for women (p < 0.02) and for increasing disease duration, HY, and CISI-PD severity level (p < 0.001). The SEM was 13.91 for total score and 1.71 to 4.73 for domains. CONCLUSION: The Non-Motor Symptoms Scale is an acceptable, reproducible, valid, and precise assessment instrument for nonmotor symptoms in Parkinson disease.",
author = "P. Martinez-Martin and C. Rodriguez-Blazquez and K. Abe and Bhattacharyya, {K. B.} and Bloem, {B. R.} and Carod-Artal, {F. J.} and R. Prakash and Esselink, {R. A.J.} and C. Falup-Pecurariu and M. Gallardo and P. Mir and Y. Naidu and A. Nicoletti and Sethi, {Kapil Dev} and Y. Tsuboi and {Van Hilten}, {J. J.} and M. Visser and M. Zappia and Chaudhuri, {K. R.}",
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T1 - International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease

AU - Martinez-Martin, P.

AU - Rodriguez-Blazquez, C.

AU - Abe, K.

AU - Bhattacharyya, K. B.

AU - Bloem, B. R.

AU - Carod-Artal, F. J.

AU - Prakash, R.

AU - Esselink, R. A.J.

AU - Falup-Pecurariu, C.

AU - Gallardo, M.

AU - Mir, P.

AU - Naidu, Y.

AU - Nicoletti, A.

AU - Sethi, Kapil Dev

AU - Tsuboi, Y.

AU - Van Hilten, J. J.

AU - Visser, M.

AU - Zappia, M.

AU - Chaudhuri, K. R.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - BACKGROUND: Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study. METHODS: Data were collected in 12 centers across 10 countries in America, Asia, and Europe. In addition to the NMSS, the following measures were applied: Scales for Outcomes in Parkinson's Disease (SCOPA)-Motor, SCOPA-Psychiatric Complications (SCOPA-PC), SCOPA-Cognition, Hoehn and Yahr Staging (HY), Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD), SCOPA-Autonomic, Parkinson's Disease Sleep Scale (PDSS), Parkinson's Disease Questionnaire-39 items (PDQ-39), and EuroQol-5 dimensions (EQ-5D). NMSS acceptability, reliability, validity, and precision were analyzed. RESULTS: Four hundred eleven patients with PD, 61.3% men, were recruited. The mean age was 64.5 ± 9.9 years, and mean disease duration was 8.1 ± 5.7 years. The NMSS score was 57.1 ± 44.0 points. The scale was free of floor or ceiling effects. For domains, the Cronbach α coefficient ranged from 0.44 to 0.85. The intraclass correlation coefficient (0.90 for the total score, 0.67-0.91 for domains) and Lin concordance coefficient (0.88) suggested satisfactory reproducibility. The NMSS total score correlated significantly with SCOPA-Autonomic, PDQ-39, and EQ-5D (rS = 0.57-0.70). Association was close between NMSS domains and the corresponding SCOPA-Autonomic domains (rS = 0.51-0.65) and also with scales measuring related constructs (PDSS, SCOPA-PC) (all p < 0.0001). The NMSS total score was higher for women (p < 0.02) and for increasing disease duration, HY, and CISI-PD severity level (p < 0.001). The SEM was 13.91 for total score and 1.71 to 4.73 for domains. CONCLUSION: The Non-Motor Symptoms Scale is an acceptable, reproducible, valid, and precise assessment instrument for nonmotor symptoms in Parkinson disease.

AB - BACKGROUND: Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study. METHODS: Data were collected in 12 centers across 10 countries in America, Asia, and Europe. In addition to the NMSS, the following measures were applied: Scales for Outcomes in Parkinson's Disease (SCOPA)-Motor, SCOPA-Psychiatric Complications (SCOPA-PC), SCOPA-Cognition, Hoehn and Yahr Staging (HY), Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD), SCOPA-Autonomic, Parkinson's Disease Sleep Scale (PDSS), Parkinson's Disease Questionnaire-39 items (PDQ-39), and EuroQol-5 dimensions (EQ-5D). NMSS acceptability, reliability, validity, and precision were analyzed. RESULTS: Four hundred eleven patients with PD, 61.3% men, were recruited. The mean age was 64.5 ± 9.9 years, and mean disease duration was 8.1 ± 5.7 years. The NMSS score was 57.1 ± 44.0 points. The scale was free of floor or ceiling effects. For domains, the Cronbach α coefficient ranged from 0.44 to 0.85. The intraclass correlation coefficient (0.90 for the total score, 0.67-0.91 for domains) and Lin concordance coefficient (0.88) suggested satisfactory reproducibility. The NMSS total score correlated significantly with SCOPA-Autonomic, PDQ-39, and EQ-5D (rS = 0.57-0.70). Association was close between NMSS domains and the corresponding SCOPA-Autonomic domains (rS = 0.51-0.65) and also with scales measuring related constructs (PDSS, SCOPA-PC) (all p < 0.0001). The NMSS total score was higher for women (p < 0.02) and for increasing disease duration, HY, and CISI-PD severity level (p < 0.001). The SEM was 13.91 for total score and 1.71 to 4.73 for domains. CONCLUSION: The Non-Motor Symptoms Scale is an acceptable, reproducible, valid, and precise assessment instrument for nonmotor symptoms in Parkinson disease.

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