Intrafamilial and case-control association analysis of d2s152 in insulin-dependent diabetes

De Fang Luo, Noel K. Maclaren, Hong So Huang, Andrew Muir, Jin Xiong She

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We have performed intrafamilial and ease-control association studies to examine the previously reported linkage disequilibrium between D2S152 and a type 1 diabetes susceptibility gene on chromosome 2q31-q33 (IDDM7). Significant linkage disequilibrium was observed in our subset of 47 Florida affected sibpair families (p < 0.02) but not in the other 57 USA families. We were not able to detect any significant associations between IDDM and D2S152 using case-control studies in a Caucasian data set of 270 unrelated diabetic patients and 370 normal controls ascertained from Florida, or in a Chinese data set of 90 patients and 169 normal controls. Our results suggest that linkage disequilibrium between IDDM7 and D2S152 must be very loose.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalAutoimmunity
Volume21
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Affected sibpair analysis
  • Diabetes
  • Genetic mapping
  • Genetic susceptibility
  • Microsatellite Markers
  • Multifactorial disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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