Intrafamilial and case-control association analysis of d2s152 in insulin-dependent diabetes

De Fang Luo; Noel K. Maclaren; Hong So Huang; Andrew Muir; Jin Xiong She

doi:10.3109/08916939508993363

Intrafamilial and case-control association analysis of d2s152 in insulin-dependent diabetes

De Fang Luo, Noel K. Maclaren, Hong So Huang, Andrew Muir, Jin Xiong She

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We have performed intrafamilial and ease-control association studies to examine the previously reported linkage disequilibrium between D2S152 and a type 1 diabetes susceptibility gene on chromosome 2q31-q33 (IDDM7). Significant linkage disequilibrium was observed in our subset of 47 Florida affected sibpair families (p < 0.02) but not in the other 57 USA families. We were not able to detect any significant associations between IDDM and D2S152 using case-control studies in a Caucasian data set of 270 unrelated diabetic patients and 370 normal controls ascertained from Florida, or in a Chinese data set of 90 patients and 169 normal controls. Our results suggest that linkage disequilibrium between IDDM7 and D2S152 must be very loose.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Autoimmunity
Volume	21
Issue number	2
DOIs	https://doi.org/10.3109/08916939508993363
State	Published - 1995
Externally published	Yes

Keywords

Affected sibpair analysis
Diabetes
Genetic mapping
Genetic susceptibility
Microsatellite Markers
Multifactorial disease

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/08916939508993363

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title = "Intrafamilial and case-control association analysis of d2s152 in insulin-dependent diabetes",

abstract = "We have performed intrafamilial and ease-control association studies to examine the previously reported linkage disequilibrium between D2S152 and a type 1 diabetes susceptibility gene on chromosome 2q31-q33 (IDDM7). Significant linkage disequilibrium was observed in our subset of 47 Florida affected sibpair families (p < 0.02) but not in the other 57 USA families. We were not able to detect any significant associations between IDDM and D2S152 using case-control studies in a Caucasian data set of 270 unrelated diabetic patients and 370 normal controls ascertained from Florida, or in a Chinese data set of 90 patients and 169 normal controls. Our results suggest that linkage disequilibrium between IDDM7 and D2S152 must be very loose.",

keywords = "Affected sibpair analysis, Diabetes, Genetic mapping, Genetic susceptibility, Microsatellite Markers, Multifactorial disease",

author = "Luo, {De Fang} and Maclaren, {Noel K.} and Huang, {Hong So} and Andrew Muir and She, {Jin Xiong}",

note = "Funding Information: This work was supported by Juvenile Diabetes Foundation grant JDF193182 (J.X.S.) and Mational Institutc of Health grant HD19469 (N.K.M.). We are grateful to Dr Richard S. Spielman at University of Pennsylvania School of Medicine for providing DNA samples from 8 IDDM families. We also thank Dr James Wcber in the Marshfield Medical Research Foundation for his help on microsatellite typing techniques.",

year = "1995",

doi = "10.3109/08916939508993363",

language = "English (US)",

volume = "21",

pages = "143--147",

journal = "Autoimmunity",

issn = "0891-6934",

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TY - JOUR

T1 - Intrafamilial and case-control association analysis of d2s152 in insulin-dependent diabetes

AU - Luo, De Fang

AU - Maclaren, Noel K.

AU - Huang, Hong So

AU - Muir, Andrew

AU - She, Jin Xiong

N1 - Funding Information: This work was supported by Juvenile Diabetes Foundation grant JDF193182 (J.X.S.) and Mational Institutc of Health grant HD19469 (N.K.M.). We are grateful to Dr Richard S. Spielman at University of Pennsylvania School of Medicine for providing DNA samples from 8 IDDM families. We also thank Dr James Wcber in the Marshfield Medical Research Foundation for his help on microsatellite typing techniques.

PY - 1995

Y1 - 1995

N2 - We have performed intrafamilial and ease-control association studies to examine the previously reported linkage disequilibrium between D2S152 and a type 1 diabetes susceptibility gene on chromosome 2q31-q33 (IDDM7). Significant linkage disequilibrium was observed in our subset of 47 Florida affected sibpair families (p < 0.02) but not in the other 57 USA families. We were not able to detect any significant associations between IDDM and D2S152 using case-control studies in a Caucasian data set of 270 unrelated diabetic patients and 370 normal controls ascertained from Florida, or in a Chinese data set of 90 patients and 169 normal controls. Our results suggest that linkage disequilibrium between IDDM7 and D2S152 must be very loose.

AB - We have performed intrafamilial and ease-control association studies to examine the previously reported linkage disequilibrium between D2S152 and a type 1 diabetes susceptibility gene on chromosome 2q31-q33 (IDDM7). Significant linkage disequilibrium was observed in our subset of 47 Florida affected sibpair families (p < 0.02) but not in the other 57 USA families. We were not able to detect any significant associations between IDDM and D2S152 using case-control studies in a Caucasian data set of 270 unrelated diabetic patients and 370 normal controls ascertained from Florida, or in a Chinese data set of 90 patients and 169 normal controls. Our results suggest that linkage disequilibrium between IDDM7 and D2S152 must be very loose.

KW - Affected sibpair analysis

KW - Diabetes

KW - Genetic mapping

KW - Genetic susceptibility

KW - Microsatellite Markers

KW - Multifactorial disease

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JF - Autoimmunity

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Intrafamilial and case-control association analysis of d2s152 in insulin-dependent diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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