Intraovarian markers of follicular and oocyte maturation

Antonio Pellicer, Michael Peter Diamond, Alan H. DeCherney, Frederick Naftolin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The use of ovulation induction for multiple follicular growth in in vitro fertilization (IVF) has introduced the problem of follicular asynchrony. As a consequence of the asynchrony, the parameters most commonly used by IVF groups to assess follicular and oocyte quality within those follicles are not sufficiently sensitive or specific. Thus, each follicle must be considered separately, and specific markers of follicular and/or oocyte maturation must be sought from within the follicle. In this review we analyze previous reports of potential markers of follicular and oocyte maturation. In regards to the follicular fluid constituents, the level of estradiol in follicular fluid correlates with fertilization and pregnancy in stimulated cycles. Other steroids are only helpful when specific stimulation protocols are used. The level of some follicular proteins such as alpha-1-antitrypsin and fibrinogen also correlates with fertilization and pregnancy outcome. Cyclic AMP levels in follicular fluid are significantly reduced in follicles leading to conception. Regulators of oocyte maturation, such as the Oocyte Maturation Inhibitor (OMI) or the Meiosis Inducing Substance (MIS) have also been correlated with IVF outcome, but their exact structure remains still unknown. In addition, other sophisticated parameters, such as chemotactic activity of human leukocytes, or simple methods, such as the presence of intrafollicular echoes, have also been used as successful markers in predicting IVF outcome.

Original languageEnglish (US)
Pages (from-to)205-217
Number of pages13
JournalJournal of in Vitro Fertilization and Embryo Transfer
Volume4
Issue number4
DOIs
StatePublished - Aug 1 1987
Externally publishedYes

Fingerprint

Fertilization in Vitro
Follicular Fluid
Oocytes
Fertilization
alpha 1-Antitrypsin
Ovulation Induction
Meiosis
Pregnancy Outcome
Human Activities
Cyclic AMP
Fibrinogen
Estradiol
Leukocytes
Steroids
Pregnancy
Growth
Proteins

Keywords

  • follicular and oocyte maturation
  • in vitro fertilization
  • intrafollicular markers

ASJC Scopus subject areas

  • Embryology
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Intraovarian markers of follicular and oocyte maturation. / Pellicer, Antonio; Diamond, Michael Peter; DeCherney, Alan H.; Naftolin, Frederick.

In: Journal of in Vitro Fertilization and Embryo Transfer, Vol. 4, No. 4, 01.08.1987, p. 205-217.

Research output: Contribution to journalArticle

Pellicer, Antonio ; Diamond, Michael Peter ; DeCherney, Alan H. ; Naftolin, Frederick. / Intraovarian markers of follicular and oocyte maturation. In: Journal of in Vitro Fertilization and Embryo Transfer. 1987 ; Vol. 4, No. 4. pp. 205-217.
@article{1daf6084aecf4a7190aa2cabd906bfd0,
title = "Intraovarian markers of follicular and oocyte maturation",
abstract = "The use of ovulation induction for multiple follicular growth in in vitro fertilization (IVF) has introduced the problem of follicular asynchrony. As a consequence of the asynchrony, the parameters most commonly used by IVF groups to assess follicular and oocyte quality within those follicles are not sufficiently sensitive or specific. Thus, each follicle must be considered separately, and specific markers of follicular and/or oocyte maturation must be sought from within the follicle. In this review we analyze previous reports of potential markers of follicular and oocyte maturation. In regards to the follicular fluid constituents, the level of estradiol in follicular fluid correlates with fertilization and pregnancy in stimulated cycles. Other steroids are only helpful when specific stimulation protocols are used. The level of some follicular proteins such as alpha-1-antitrypsin and fibrinogen also correlates with fertilization and pregnancy outcome. Cyclic AMP levels in follicular fluid are significantly reduced in follicles leading to conception. Regulators of oocyte maturation, such as the Oocyte Maturation Inhibitor (OMI) or the Meiosis Inducing Substance (MIS) have also been correlated with IVF outcome, but their exact structure remains still unknown. In addition, other sophisticated parameters, such as chemotactic activity of human leukocytes, or simple methods, such as the presence of intrafollicular echoes, have also been used as successful markers in predicting IVF outcome.",
keywords = "follicular and oocyte maturation, in vitro fertilization, intrafollicular markers",
author = "Antonio Pellicer and Diamond, {Michael Peter} and DeCherney, {Alan H.} and Frederick Naftolin",
year = "1987",
month = "8",
day = "1",
doi = "10.1007/BF01533758",
language = "English (US)",
volume = "4",
pages = "205--217",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Intraovarian markers of follicular and oocyte maturation

AU - Pellicer, Antonio

AU - Diamond, Michael Peter

AU - DeCherney, Alan H.

AU - Naftolin, Frederick

PY - 1987/8/1

Y1 - 1987/8/1

N2 - The use of ovulation induction for multiple follicular growth in in vitro fertilization (IVF) has introduced the problem of follicular asynchrony. As a consequence of the asynchrony, the parameters most commonly used by IVF groups to assess follicular and oocyte quality within those follicles are not sufficiently sensitive or specific. Thus, each follicle must be considered separately, and specific markers of follicular and/or oocyte maturation must be sought from within the follicle. In this review we analyze previous reports of potential markers of follicular and oocyte maturation. In regards to the follicular fluid constituents, the level of estradiol in follicular fluid correlates with fertilization and pregnancy in stimulated cycles. Other steroids are only helpful when specific stimulation protocols are used. The level of some follicular proteins such as alpha-1-antitrypsin and fibrinogen also correlates with fertilization and pregnancy outcome. Cyclic AMP levels in follicular fluid are significantly reduced in follicles leading to conception. Regulators of oocyte maturation, such as the Oocyte Maturation Inhibitor (OMI) or the Meiosis Inducing Substance (MIS) have also been correlated with IVF outcome, but their exact structure remains still unknown. In addition, other sophisticated parameters, such as chemotactic activity of human leukocytes, or simple methods, such as the presence of intrafollicular echoes, have also been used as successful markers in predicting IVF outcome.

AB - The use of ovulation induction for multiple follicular growth in in vitro fertilization (IVF) has introduced the problem of follicular asynchrony. As a consequence of the asynchrony, the parameters most commonly used by IVF groups to assess follicular and oocyte quality within those follicles are not sufficiently sensitive or specific. Thus, each follicle must be considered separately, and specific markers of follicular and/or oocyte maturation must be sought from within the follicle. In this review we analyze previous reports of potential markers of follicular and oocyte maturation. In regards to the follicular fluid constituents, the level of estradiol in follicular fluid correlates with fertilization and pregnancy in stimulated cycles. Other steroids are only helpful when specific stimulation protocols are used. The level of some follicular proteins such as alpha-1-antitrypsin and fibrinogen also correlates with fertilization and pregnancy outcome. Cyclic AMP levels in follicular fluid are significantly reduced in follicles leading to conception. Regulators of oocyte maturation, such as the Oocyte Maturation Inhibitor (OMI) or the Meiosis Inducing Substance (MIS) have also been correlated with IVF outcome, but their exact structure remains still unknown. In addition, other sophisticated parameters, such as chemotactic activity of human leukocytes, or simple methods, such as the presence of intrafollicular echoes, have also been used as successful markers in predicting IVF outcome.

KW - follicular and oocyte maturation

KW - in vitro fertilization

KW - intrafollicular markers

UR - http://www.scopus.com/inward/record.url?scp=0023394558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023394558&partnerID=8YFLogxK

U2 - 10.1007/BF01533758

DO - 10.1007/BF01533758

M3 - Article

C2 - 3040874

AN - SCOPUS:0023394558

VL - 4

SP - 205

EP - 217

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 4

ER -