Introduction: Determinants of polycystic ovary syndrome

Ricardo Azziz

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrine abnormalities of humans, with global prevalences so far generally 5%–15%. Overall, the disorder appears to be an ancient complex genetic trait, perhaps dating at least 50,000 years ago. The phenotype of PCOS can be subdivided into four different types. Phenotype A and B (hyperandrogenism + ovulatory dysfunction, with [A] and without [B] polycystic ovarian morphology [PCOM], respectively) can be considered to represent the “classic” form of the disorder. Phenotype C is the so-called “ovulatory” PCOS (hyperandrogenism + PCOM only). And phenotype D is often referred to as “nonhyperandrogenic” PCOS (ovulatory dysfunction + PCOM only). The different phenotypes vary in the degree to which they are associated with an increased risk for metabolic dysfunction and reproductive complications. There are a number of determinants of the epidemiology (prevalence) and presentation (phenotype) of PCOS, including environmental (e.g., socioeconomic, geographic, toxicologic, life-style, and dietary) and genetic (e.g., gene variants, epigenetic, and race/ethnicity) factors. Finally a better understanding of the evolutionary determinants of PCOS has the potential for providing additional insight into those factors determining the etiology, prevalence, and persistence of a disorder that appears to be, superficially at least, an evolutionary paradox.

Original languageEnglish (US)
Pages (from-to)4-5
Number of pages2
JournalFertility and sterility
Volume106
Issue number1
DOIs
StatePublished - Jul 1 2016

Keywords

  • PCOS
  • epigenetics
  • evolution
  • genetics
  • genotype
  • phenotype
  • polycystic ovary syndrome
  • socioeconomics
  • toxicological

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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