Introduction to cell therapy in brain injury

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell therapy represents a “third wave” of therapeutics following in the wake of the “small molecule” and “biologicals” approaches. Cell therapy targets the reparative and remodeling phase of brain injury. In this book, we cover the use of different types of “cells” from bone-marrow-derived cells such as bone marrow mononuclear cells, mesenchymal stem cells (or marrow stromal cells), and MultiStem, a proprietary plastic adherent cell, to neural stem cells, including induced pluripotent stem (iPS) cell-derived neural progenitors. We also include a chapter on the use of the conditioned media of adipose stem cells as a cell-based therapeutic approach. Different cell types justify different routes of administration (intravenous, intra-arterial, and intracerebral), and there are multiple time windows of intervention. While most of preclinical work and early clinical trials on cell therapy has been with adult stroke, we also include chapters on the use of cell therapy in traumatic brain injury, neonatal stroke, and neonatal hypoxic–ischemic encephalopathy. While cell therapy has enormous potential to improve the quality of life of many with brain injury, the field has suffered from too much “hype.” Only high-quality and rigorous preclinical studies followed by well-designed clinical trials will allow the field to advance, mature, and hopefully develop treatments to reduce disability.

Original languageEnglish (US)
Title of host publicationCell Therapy for Brain Injury
PublisherSpringer International Publishing
Pages1-9
Number of pages9
ISBN (Electronic)9783319150635
ISBN (Print)9783319150628
DOIs
StatePublished - Jan 1 2015

Fingerprint

Cell- and Tissue-Based Therapy
Stem cells
Brain Injuries
Brain
Bone
Bone Marrow Cells
Stroke
Clinical Trials
Conditioned Culture Medium
Induced Pluripotent Stem Cells
Neural Stem Cells
Brain Diseases
Stromal Cells
Mesenchymal Stromal Cells
Intravenous Administration
Plastics
Stem Cells
Therapeutics
Bone Marrow
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Hess, D. C. (2015). Introduction to cell therapy in brain injury. In Cell Therapy for Brain Injury (pp. 1-9). Springer International Publishing. https://doi.org/10.1007/978-3-319-15063-5_1

Introduction to cell therapy in brain injury. / Hess, David C.

Cell Therapy for Brain Injury. Springer International Publishing, 2015. p. 1-9.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hess, DC 2015, Introduction to cell therapy in brain injury. in Cell Therapy for Brain Injury. Springer International Publishing, pp. 1-9. https://doi.org/10.1007/978-3-319-15063-5_1
Hess DC. Introduction to cell therapy in brain injury. In Cell Therapy for Brain Injury. Springer International Publishing. 2015. p. 1-9 https://doi.org/10.1007/978-3-319-15063-5_1
Hess, David C. / Introduction to cell therapy in brain injury. Cell Therapy for Brain Injury. Springer International Publishing, 2015. pp. 1-9
@inbook{814eedfeff2048f0a36e027fedd3d150,
title = "Introduction to cell therapy in brain injury",
abstract = "Cell therapy represents a “third wave” of therapeutics following in the wake of the “small molecule” and “biologicals” approaches. Cell therapy targets the reparative and remodeling phase of brain injury. In this book, we cover the use of different types of “cells” from bone-marrow-derived cells such as bone marrow mononuclear cells, mesenchymal stem cells (or marrow stromal cells), and MultiStem, a proprietary plastic adherent cell, to neural stem cells, including induced pluripotent stem (iPS) cell-derived neural progenitors. We also include a chapter on the use of the conditioned media of adipose stem cells as a cell-based therapeutic approach. Different cell types justify different routes of administration (intravenous, intra-arterial, and intracerebral), and there are multiple time windows of intervention. While most of preclinical work and early clinical trials on cell therapy has been with adult stroke, we also include chapters on the use of cell therapy in traumatic brain injury, neonatal stroke, and neonatal hypoxic–ischemic encephalopathy. While cell therapy has enormous potential to improve the quality of life of many with brain injury, the field has suffered from too much “hype.” Only high-quality and rigorous preclinical studies followed by well-designed clinical trials will allow the field to advance, mature, and hopefully develop treatments to reduce disability.",
author = "Hess, {David C}",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-15063-5_1",
language = "English (US)",
isbn = "9783319150628",
pages = "1--9",
booktitle = "Cell Therapy for Brain Injury",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Introduction to cell therapy in brain injury

AU - Hess, David C

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Cell therapy represents a “third wave” of therapeutics following in the wake of the “small molecule” and “biologicals” approaches. Cell therapy targets the reparative and remodeling phase of brain injury. In this book, we cover the use of different types of “cells” from bone-marrow-derived cells such as bone marrow mononuclear cells, mesenchymal stem cells (or marrow stromal cells), and MultiStem, a proprietary plastic adherent cell, to neural stem cells, including induced pluripotent stem (iPS) cell-derived neural progenitors. We also include a chapter on the use of the conditioned media of adipose stem cells as a cell-based therapeutic approach. Different cell types justify different routes of administration (intravenous, intra-arterial, and intracerebral), and there are multiple time windows of intervention. While most of preclinical work and early clinical trials on cell therapy has been with adult stroke, we also include chapters on the use of cell therapy in traumatic brain injury, neonatal stroke, and neonatal hypoxic–ischemic encephalopathy. While cell therapy has enormous potential to improve the quality of life of many with brain injury, the field has suffered from too much “hype.” Only high-quality and rigorous preclinical studies followed by well-designed clinical trials will allow the field to advance, mature, and hopefully develop treatments to reduce disability.

AB - Cell therapy represents a “third wave” of therapeutics following in the wake of the “small molecule” and “biologicals” approaches. Cell therapy targets the reparative and remodeling phase of brain injury. In this book, we cover the use of different types of “cells” from bone-marrow-derived cells such as bone marrow mononuclear cells, mesenchymal stem cells (or marrow stromal cells), and MultiStem, a proprietary plastic adherent cell, to neural stem cells, including induced pluripotent stem (iPS) cell-derived neural progenitors. We also include a chapter on the use of the conditioned media of adipose stem cells as a cell-based therapeutic approach. Different cell types justify different routes of administration (intravenous, intra-arterial, and intracerebral), and there are multiple time windows of intervention. While most of preclinical work and early clinical trials on cell therapy has been with adult stroke, we also include chapters on the use of cell therapy in traumatic brain injury, neonatal stroke, and neonatal hypoxic–ischemic encephalopathy. While cell therapy has enormous potential to improve the quality of life of many with brain injury, the field has suffered from too much “hype.” Only high-quality and rigorous preclinical studies followed by well-designed clinical trials will allow the field to advance, mature, and hopefully develop treatments to reduce disability.

UR - http://www.scopus.com/inward/record.url?scp=84943382843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943382843&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-15063-5_1

DO - 10.1007/978-3-319-15063-5_1

M3 - Chapter

SN - 9783319150628

SP - 1

EP - 9

BT - Cell Therapy for Brain Injury

PB - Springer International Publishing

ER -