Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy

Results of the adaptive CRT trial

David O. Martin, Bernd Lemke, David Birnie, Henry Krum, Kathy Lai Fun Lee, Kazutaka Aonuma, Maurizio Gasparini, Randall C. Starling, Goran Milasinovic, Tyson Rogers, Alex Sambelashvili, John Gorcsan, Mahmoud Houmsse, P. Wells, A. Merliss, I. Khan, J. Stone, D. Rodak, S. Lee, S. Milstein & 80 others T. Svinarich, D. Lustgarten, Robert A Sorrentino, J. McKenzie, J. Hobson, J. S. Allison, De Bruyn Van De Bruyn, T. Lessmeier, W. Johnson, S. Goel, M. Emert, R. Lerman, M. Chaudhry, S. Klein, M. Imburgia, M. Gold, L. Zaman, B. Ramza, J. Bailey, D. Bello, B. Foreman, R. Kawasaki, J. Lobban, J. Curwin, G. Turitto, J. Lowy, S. Karanam, E. Putz, J. Collier, J. Simonson, B. Mikaelian, S. Compton, L. Pires, J. Walsh, M. Wadhwa, J. Herre, R. Canby, K. Bruce, J. Sims, R. Carney, A. Bank, M. Borganelli, W. Clair, R. Shepard, J. Cheung, D. Elmouchi, F. Heath, A. Kypta, P. T. Mortensen, F. Voss, T. Lawo, L. H. Bouwels, M. E. Landolina, S. Faerestrand, M. Gil, D. V. Kovacevic, J. Hörnsten, Z. Perisic, H. Nägele, M. Scheffer, A. Brandes, E. Kongsgård, C. Hassager, A. Hersi, V. A. Kuznetsov, M. A. Aydin, R. Borgquist, W. Mullens, V. Paul, M. Kilborn, J. Hayes, B. Walker, R. Denman, P. Sanders, R. Yee, Y. Khaykin, G. Sumner, A. Tang, S. Kamakura, H. F. Tse

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background: In patients with sinus rhythm and normal atrioventricular conduction, pacing only the left ventricle with appropriate atrioventricular delays can result in superior left ventricular and right ventricular function compared with standard biventricular (BiV) pacing. Objective: To evaluate a novel adaptive cardiac resynchronization therapy ((aCRT) algorithm for CRT pacing that provides automatic ambulatory selection between synchronized left ventricular or BiV pacing with dynamic optimization of atrioventricular and interventricular delays. Methods: Patients (n = 522) indicated for a CRT-defibrillator were randomized to aCRT vs echo-optimized BiV pacing (Echo) in a 2:1 ratio and followed at 1-, 3-, and 6-month postrandomization. Results: The study met all 3 noninferiority primary objectives: (1) the percentage of aCRT patients who improved in their clinical composite score at 6 months was at least as high in the aCRT arm as in the Echo arm (73.6% vs 72.5%, with a noninferiority margin of 12%; P =.0007); (2) aCRT and echo-optimized settings resulted in similar cardiac performance, as demonstrated by a high concordance correlation coefficient between aortic velocity time integrals at aCRT and Echo settings at randomization (concordance correlation coefficient = 0.93; 95% confidence interval 0.91-0.94) and at 6-month postrandomization (concordance correlation coefficient = 0.90; 95% confidence interval 0.87-0.92); and (3) aCRT did not result in inappropriate device settings. There were no significant differences between the arms with respect to heart failure events or ventricular arrhythmia episodes. Secondary end points showed similar benefit, and right-ventricular pacing was reduced by 44% in the aCRT arm. Conclusions: The aCRT algorithm is safe and at least as effective as BiV pacing with comprehensive echocardiographic optimization.

Original languageEnglish (US)
JournalHeart Rhythm
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2012

Fingerprint

Cardiac Resynchronization Therapy
Confidence Intervals
Right Ventricular Function
Defibrillators
Random Allocation
Heart Ventricles
Cardiac Arrhythmias

Keywords

  • Cardiac resynchronization therapy
  • Fusion pacing
  • Heart failure
  • LV pacing
  • Optimization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy : Results of the adaptive CRT trial. / Martin, David O.; Lemke, Bernd; Birnie, David; Krum, Henry; Lee, Kathy Lai Fun; Aonuma, Kazutaka; Gasparini, Maurizio; Starling, Randall C.; Milasinovic, Goran; Rogers, Tyson; Sambelashvili, Alex; Gorcsan, John; Houmsse, Mahmoud; Wells, P.; Merliss, A.; Khan, I.; Stone, J.; Rodak, D.; Lee, S.; Milstein, S.; Svinarich, T.; Lustgarten, D.; Sorrentino, Robert A; McKenzie, J.; Hobson, J.; Allison, J. S.; Van De Bruyn, De Bruyn; Lessmeier, T.; Johnson, W.; Goel, S.; Emert, M.; Lerman, R.; Chaudhry, M.; Klein, S.; Imburgia, M.; Gold, M.; Zaman, L.; Ramza, B.; Bailey, J.; Bello, D.; Foreman, B.; Kawasaki, R.; Lobban, J.; Curwin, J.; Turitto, G.; Lowy, J.; Karanam, S.; Putz, E.; Collier, J.; Simonson, J.; Mikaelian, B.; Compton, S.; Pires, L.; Walsh, J.; Wadhwa, M.; Herre, J.; Canby, R.; Bruce, K.; Sims, J.; Carney, R.; Bank, A.; Borganelli, M.; Clair, W.; Shepard, R.; Cheung, J.; Elmouchi, D.; Heath, F.; Kypta, A.; Mortensen, P. T.; Voss, F.; Lawo, T.; Bouwels, L. H.; Landolina, M. E.; Faerestrand, S.; Gil, M.; Kovacevic, D. V.; Hörnsten, J.; Perisic, Z.; Nägele, H.; Scheffer, M.; Brandes, A.; Kongsgård, E.; Hassager, C.; Hersi, A.; Kuznetsov, V. A.; Aydin, M. A.; Borgquist, R.; Mullens, W.; Paul, V.; Kilborn, M.; Hayes, J.; Walker, B.; Denman, R.; Sanders, P.; Yee, R.; Khaykin, Y.; Sumner, G.; Tang, A.; Kamakura, S.; Tse, H. F.

In: Heart Rhythm, Vol. 9, No. 11, 01.11.2012.

Research output: Contribution to journalArticle

Martin, DO, Lemke, B, Birnie, D, Krum, H, Lee, KLF, Aonuma, K, Gasparini, M, Starling, RC, Milasinovic, G, Rogers, T, Sambelashvili, A, Gorcsan, J, Houmsse, M, Wells, P, Merliss, A, Khan, I, Stone, J, Rodak, D, Lee, S, Milstein, S, Svinarich, T, Lustgarten, D, Sorrentino, RA, McKenzie, J, Hobson, J, Allison, JS, Van De Bruyn, DB, Lessmeier, T, Johnson, W, Goel, S, Emert, M, Lerman, R, Chaudhry, M, Klein, S, Imburgia, M, Gold, M, Zaman, L, Ramza, B, Bailey, J, Bello, D, Foreman, B, Kawasaki, R, Lobban, J, Curwin, J, Turitto, G, Lowy, J, Karanam, S, Putz, E, Collier, J, Simonson, J, Mikaelian, B, Compton, S, Pires, L, Walsh, J, Wadhwa, M, Herre, J, Canby, R, Bruce, K, Sims, J, Carney, R, Bank, A, Borganelli, M, Clair, W, Shepard, R, Cheung, J, Elmouchi, D, Heath, F, Kypta, A, Mortensen, PT, Voss, F, Lawo, T, Bouwels, LH, Landolina, ME, Faerestrand, S, Gil, M, Kovacevic, DV, Hörnsten, J, Perisic, Z, Nägele, H, Scheffer, M, Brandes, A, Kongsgård, E, Hassager, C, Hersi, A, Kuznetsov, VA, Aydin, MA, Borgquist, R, Mullens, W, Paul, V, Kilborn, M, Hayes, J, Walker, B, Denman, R, Sanders, P, Yee, R, Khaykin, Y, Sumner, G, Tang, A, Kamakura, S & Tse, HF 2012, 'Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: Results of the adaptive CRT trial', Heart Rhythm, vol. 9, no. 11. https://doi.org/10.1016/j.hrthm.2012.07.009
Martin, David O. ; Lemke, Bernd ; Birnie, David ; Krum, Henry ; Lee, Kathy Lai Fun ; Aonuma, Kazutaka ; Gasparini, Maurizio ; Starling, Randall C. ; Milasinovic, Goran ; Rogers, Tyson ; Sambelashvili, Alex ; Gorcsan, John ; Houmsse, Mahmoud ; Wells, P. ; Merliss, A. ; Khan, I. ; Stone, J. ; Rodak, D. ; Lee, S. ; Milstein, S. ; Svinarich, T. ; Lustgarten, D. ; Sorrentino, Robert A ; McKenzie, J. ; Hobson, J. ; Allison, J. S. ; Van De Bruyn, De Bruyn ; Lessmeier, T. ; Johnson, W. ; Goel, S. ; Emert, M. ; Lerman, R. ; Chaudhry, M. ; Klein, S. ; Imburgia, M. ; Gold, M. ; Zaman, L. ; Ramza, B. ; Bailey, J. ; Bello, D. ; Foreman, B. ; Kawasaki, R. ; Lobban, J. ; Curwin, J. ; Turitto, G. ; Lowy, J. ; Karanam, S. ; Putz, E. ; Collier, J. ; Simonson, J. ; Mikaelian, B. ; Compton, S. ; Pires, L. ; Walsh, J. ; Wadhwa, M. ; Herre, J. ; Canby, R. ; Bruce, K. ; Sims, J. ; Carney, R. ; Bank, A. ; Borganelli, M. ; Clair, W. ; Shepard, R. ; Cheung, J. ; Elmouchi, D. ; Heath, F. ; Kypta, A. ; Mortensen, P. T. ; Voss, F. ; Lawo, T. ; Bouwels, L. H. ; Landolina, M. E. ; Faerestrand, S. ; Gil, M. ; Kovacevic, D. V. ; Hörnsten, J. ; Perisic, Z. ; Nägele, H. ; Scheffer, M. ; Brandes, A. ; Kongsgård, E. ; Hassager, C. ; Hersi, A. ; Kuznetsov, V. A. ; Aydin, M. A. ; Borgquist, R. ; Mullens, W. ; Paul, V. ; Kilborn, M. ; Hayes, J. ; Walker, B. ; Denman, R. ; Sanders, P. ; Yee, R. ; Khaykin, Y. ; Sumner, G. ; Tang, A. ; Kamakura, S. ; Tse, H. F. / Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy : Results of the adaptive CRT trial. In: Heart Rhythm. 2012 ; Vol. 9, No. 11.
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abstract = "Background: In patients with sinus rhythm and normal atrioventricular conduction, pacing only the left ventricle with appropriate atrioventricular delays can result in superior left ventricular and right ventricular function compared with standard biventricular (BiV) pacing. Objective: To evaluate a novel adaptive cardiac resynchronization therapy ((aCRT) algorithm for CRT pacing that provides automatic ambulatory selection between synchronized left ventricular or BiV pacing with dynamic optimization of atrioventricular and interventricular delays. Methods: Patients (n = 522) indicated for a CRT-defibrillator were randomized to aCRT vs echo-optimized BiV pacing (Echo) in a 2:1 ratio and followed at 1-, 3-, and 6-month postrandomization. Results: The study met all 3 noninferiority primary objectives: (1) the percentage of aCRT patients who improved in their clinical composite score at 6 months was at least as high in the aCRT arm as in the Echo arm (73.6{\%} vs 72.5{\%}, with a noninferiority margin of 12{\%}; P =.0007); (2) aCRT and echo-optimized settings resulted in similar cardiac performance, as demonstrated by a high concordance correlation coefficient between aortic velocity time integrals at aCRT and Echo settings at randomization (concordance correlation coefficient = 0.93; 95{\%} confidence interval 0.91-0.94) and at 6-month postrandomization (concordance correlation coefficient = 0.90; 95{\%} confidence interval 0.87-0.92); and (3) aCRT did not result in inappropriate device settings. There were no significant differences between the arms with respect to heart failure events or ventricular arrhythmia episodes. Secondary end points showed similar benefit, and right-ventricular pacing was reduced by 44{\%} in the aCRT arm. Conclusions: The aCRT algorithm is safe and at least as effective as BiV pacing with comprehensive echocardiographic optimization.",
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TY - JOUR

T1 - Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy

T2 - Results of the adaptive CRT trial

AU - Martin, David O.

AU - Lemke, Bernd

AU - Birnie, David

AU - Krum, Henry

AU - Lee, Kathy Lai Fun

AU - Aonuma, Kazutaka

AU - Gasparini, Maurizio

AU - Starling, Randall C.

AU - Milasinovic, Goran

AU - Rogers, Tyson

AU - Sambelashvili, Alex

AU - Gorcsan, John

AU - Houmsse, Mahmoud

AU - Wells, P.

AU - Merliss, A.

AU - Khan, I.

AU - Stone, J.

AU - Rodak, D.

AU - Lee, S.

AU - Milstein, S.

AU - Svinarich, T.

AU - Lustgarten, D.

AU - Sorrentino, Robert A

AU - McKenzie, J.

AU - Hobson, J.

AU - Allison, J. S.

AU - Van De Bruyn, De Bruyn

AU - Lessmeier, T.

AU - Johnson, W.

AU - Goel, S.

AU - Emert, M.

AU - Lerman, R.

AU - Chaudhry, M.

AU - Klein, S.

AU - Imburgia, M.

AU - Gold, M.

AU - Zaman, L.

AU - Ramza, B.

AU - Bailey, J.

AU - Bello, D.

AU - Foreman, B.

AU - Kawasaki, R.

AU - Lobban, J.

AU - Curwin, J.

AU - Turitto, G.

AU - Lowy, J.

AU - Karanam, S.

AU - Putz, E.

AU - Collier, J.

AU - Simonson, J.

AU - Mikaelian, B.

AU - Compton, S.

AU - Pires, L.

AU - Walsh, J.

AU - Wadhwa, M.

AU - Herre, J.

AU - Canby, R.

AU - Bruce, K.

AU - Sims, J.

AU - Carney, R.

AU - Bank, A.

AU - Borganelli, M.

AU - Clair, W.

AU - Shepard, R.

AU - Cheung, J.

AU - Elmouchi, D.

AU - Heath, F.

AU - Kypta, A.

AU - Mortensen, P. T.

AU - Voss, F.

AU - Lawo, T.

AU - Bouwels, L. H.

AU - Landolina, M. E.

AU - Faerestrand, S.

AU - Gil, M.

AU - Kovacevic, D. V.

AU - Hörnsten, J.

AU - Perisic, Z.

AU - Nägele, H.

AU - Scheffer, M.

AU - Brandes, A.

AU - Kongsgård, E.

AU - Hassager, C.

AU - Hersi, A.

AU - Kuznetsov, V. A.

AU - Aydin, M. A.

AU - Borgquist, R.

AU - Mullens, W.

AU - Paul, V.

AU - Kilborn, M.

AU - Hayes, J.

AU - Walker, B.

AU - Denman, R.

AU - Sanders, P.

AU - Yee, R.

AU - Khaykin, Y.

AU - Sumner, G.

AU - Tang, A.

AU - Kamakura, S.

AU - Tse, H. F.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Background: In patients with sinus rhythm and normal atrioventricular conduction, pacing only the left ventricle with appropriate atrioventricular delays can result in superior left ventricular and right ventricular function compared with standard biventricular (BiV) pacing. Objective: To evaluate a novel adaptive cardiac resynchronization therapy ((aCRT) algorithm for CRT pacing that provides automatic ambulatory selection between synchronized left ventricular or BiV pacing with dynamic optimization of atrioventricular and interventricular delays. Methods: Patients (n = 522) indicated for a CRT-defibrillator were randomized to aCRT vs echo-optimized BiV pacing (Echo) in a 2:1 ratio and followed at 1-, 3-, and 6-month postrandomization. Results: The study met all 3 noninferiority primary objectives: (1) the percentage of aCRT patients who improved in their clinical composite score at 6 months was at least as high in the aCRT arm as in the Echo arm (73.6% vs 72.5%, with a noninferiority margin of 12%; P =.0007); (2) aCRT and echo-optimized settings resulted in similar cardiac performance, as demonstrated by a high concordance correlation coefficient between aortic velocity time integrals at aCRT and Echo settings at randomization (concordance correlation coefficient = 0.93; 95% confidence interval 0.91-0.94) and at 6-month postrandomization (concordance correlation coefficient = 0.90; 95% confidence interval 0.87-0.92); and (3) aCRT did not result in inappropriate device settings. There were no significant differences between the arms with respect to heart failure events or ventricular arrhythmia episodes. Secondary end points showed similar benefit, and right-ventricular pacing was reduced by 44% in the aCRT arm. Conclusions: The aCRT algorithm is safe and at least as effective as BiV pacing with comprehensive echocardiographic optimization.

AB - Background: In patients with sinus rhythm and normal atrioventricular conduction, pacing only the left ventricle with appropriate atrioventricular delays can result in superior left ventricular and right ventricular function compared with standard biventricular (BiV) pacing. Objective: To evaluate a novel adaptive cardiac resynchronization therapy ((aCRT) algorithm for CRT pacing that provides automatic ambulatory selection between synchronized left ventricular or BiV pacing with dynamic optimization of atrioventricular and interventricular delays. Methods: Patients (n = 522) indicated for a CRT-defibrillator were randomized to aCRT vs echo-optimized BiV pacing (Echo) in a 2:1 ratio and followed at 1-, 3-, and 6-month postrandomization. Results: The study met all 3 noninferiority primary objectives: (1) the percentage of aCRT patients who improved in their clinical composite score at 6 months was at least as high in the aCRT arm as in the Echo arm (73.6% vs 72.5%, with a noninferiority margin of 12%; P =.0007); (2) aCRT and echo-optimized settings resulted in similar cardiac performance, as demonstrated by a high concordance correlation coefficient between aortic velocity time integrals at aCRT and Echo settings at randomization (concordance correlation coefficient = 0.93; 95% confidence interval 0.91-0.94) and at 6-month postrandomization (concordance correlation coefficient = 0.90; 95% confidence interval 0.87-0.92); and (3) aCRT did not result in inappropriate device settings. There were no significant differences between the arms with respect to heart failure events or ventricular arrhythmia episodes. Secondary end points showed similar benefit, and right-ventricular pacing was reduced by 44% in the aCRT arm. Conclusions: The aCRT algorithm is safe and at least as effective as BiV pacing with comprehensive echocardiographic optimization.

KW - Cardiac resynchronization therapy

KW - Fusion pacing

KW - Heart failure

KW - LV pacing

KW - Optimization

UR - http://www.scopus.com/inward/record.url?scp=84867859165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867859165&partnerID=8YFLogxK

U2 - 10.1016/j.hrthm.2012.07.009

DO - 10.1016/j.hrthm.2012.07.009

M3 - Article

VL - 9

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 11

ER -