Investigation of esophageal sensation and biomechanical properties in functional chest pain

I. Nasr, A. Attaluri, S. Hashmi, H. Gregersen, Satish Sanku Chander Rao

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background There is limited and conflicting data regarding the role of esophageal hypersensitivity in the pathogenesis of functional chest pain (FCP). We examined esophageal sensori-motor properties, mechanics, and symptoms in subjects with FCP. Methods Esophageal balloon distension test was performed using impedance planimetry in 189 (m/f = 57/132) consecutive subjects with non-cardiac, non-reflux chest pain, and 36 (m/f = 16/20) healthy controls. The biomechanical and sensory properties of subjects with and without esophageal hypersensitivity were compared with controls. The frequency, intensity, and duration of chest pain were assessed. Key Results One hundred and forty-three (75%) subjects had esophageal hypersensitivity and 46 (25%) had normal sensitivity. Typical chest pain was reproduced in 105/143 (74%) subjects. Subjects with hypersensitivity demonstrated larger cross-sectional area (P < 0.001), decreased esophageal wall strain (P < 0.001) and distensibility (P < 0.001), and lower thresholds for perception (P < 0.01), discomfort (P < 0.01), and pain (P < 0.01) compared to those without hypersensitivity or healthy controls. Chest pain scores (mean ± SD) for frequency, intensity and duration were 2.5 ± 0.3, 2.2 ± 0.2, and 2.2 ± 0.2, respectively, and were similar between the two patient groups. Conclusions & Inferences Seventy-five per cent of subjects with FCP demonstrate esophageal hypersensitivity. Visceral hyperalgesia and sensori-motor dysfunction of the esophagus play a key role in the pathogenesis of chest pain.

Original languageEnglish (US)
JournalNeurogastroenterology and Motility
Volume22
Issue number5
DOIs
StatePublished - May 1 2010

Fingerprint

Chest Pain
Hypersensitivity
Hyperalgesia
Mechanics
Electric Impedance
Esophagus
Pain

Keywords

  • Balloon distension test
  • Esophagus
  • Functional chest pain
  • Sensory and biomechanical properties

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Investigation of esophageal sensation and biomechanical properties in functional chest pain. / Nasr, I.; Attaluri, A.; Hashmi, S.; Gregersen, H.; Rao, Satish Sanku Chander.

In: Neurogastroenterology and Motility, Vol. 22, No. 5, 01.05.2010.

Research output: Contribution to journalArticle

@article{06f5fa5a33b744cda33596aa3ede41bd,
title = "Investigation of esophageal sensation and biomechanical properties in functional chest pain",
abstract = "Background There is limited and conflicting data regarding the role of esophageal hypersensitivity in the pathogenesis of functional chest pain (FCP). We examined esophageal sensori-motor properties, mechanics, and symptoms in subjects with FCP. Methods Esophageal balloon distension test was performed using impedance planimetry in 189 (m/f = 57/132) consecutive subjects with non-cardiac, non-reflux chest pain, and 36 (m/f = 16/20) healthy controls. The biomechanical and sensory properties of subjects with and without esophageal hypersensitivity were compared with controls. The frequency, intensity, and duration of chest pain were assessed. Key Results One hundred and forty-three (75{\%}) subjects had esophageal hypersensitivity and 46 (25{\%}) had normal sensitivity. Typical chest pain was reproduced in 105/143 (74{\%}) subjects. Subjects with hypersensitivity demonstrated larger cross-sectional area (P < 0.001), decreased esophageal wall strain (P < 0.001) and distensibility (P < 0.001), and lower thresholds for perception (P < 0.01), discomfort (P < 0.01), and pain (P < 0.01) compared to those without hypersensitivity or healthy controls. Chest pain scores (mean ± SD) for frequency, intensity and duration were 2.5 ± 0.3, 2.2 ± 0.2, and 2.2 ± 0.2, respectively, and were similar between the two patient groups. Conclusions & Inferences Seventy-five per cent of subjects with FCP demonstrate esophageal hypersensitivity. Visceral hyperalgesia and sensori-motor dysfunction of the esophagus play a key role in the pathogenesis of chest pain.",
keywords = "Balloon distension test, Esophagus, Functional chest pain, Sensory and biomechanical properties",
author = "I. Nasr and A. Attaluri and S. Hashmi and H. Gregersen and Rao, {Satish Sanku Chander}",
year = "2010",
month = "5",
day = "1",
doi = "10.1111/j.1365-2982.2009.01451.x",
language = "English (US)",
volume = "22",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Investigation of esophageal sensation and biomechanical properties in functional chest pain

AU - Nasr, I.

AU - Attaluri, A.

AU - Hashmi, S.

AU - Gregersen, H.

AU - Rao, Satish Sanku Chander

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Background There is limited and conflicting data regarding the role of esophageal hypersensitivity in the pathogenesis of functional chest pain (FCP). We examined esophageal sensori-motor properties, mechanics, and symptoms in subjects with FCP. Methods Esophageal balloon distension test was performed using impedance planimetry in 189 (m/f = 57/132) consecutive subjects with non-cardiac, non-reflux chest pain, and 36 (m/f = 16/20) healthy controls. The biomechanical and sensory properties of subjects with and without esophageal hypersensitivity were compared with controls. The frequency, intensity, and duration of chest pain were assessed. Key Results One hundred and forty-three (75%) subjects had esophageal hypersensitivity and 46 (25%) had normal sensitivity. Typical chest pain was reproduced in 105/143 (74%) subjects. Subjects with hypersensitivity demonstrated larger cross-sectional area (P < 0.001), decreased esophageal wall strain (P < 0.001) and distensibility (P < 0.001), and lower thresholds for perception (P < 0.01), discomfort (P < 0.01), and pain (P < 0.01) compared to those without hypersensitivity or healthy controls. Chest pain scores (mean ± SD) for frequency, intensity and duration were 2.5 ± 0.3, 2.2 ± 0.2, and 2.2 ± 0.2, respectively, and were similar between the two patient groups. Conclusions & Inferences Seventy-five per cent of subjects with FCP demonstrate esophageal hypersensitivity. Visceral hyperalgesia and sensori-motor dysfunction of the esophagus play a key role in the pathogenesis of chest pain.

AB - Background There is limited and conflicting data regarding the role of esophageal hypersensitivity in the pathogenesis of functional chest pain (FCP). We examined esophageal sensori-motor properties, mechanics, and symptoms in subjects with FCP. Methods Esophageal balloon distension test was performed using impedance planimetry in 189 (m/f = 57/132) consecutive subjects with non-cardiac, non-reflux chest pain, and 36 (m/f = 16/20) healthy controls. The biomechanical and sensory properties of subjects with and without esophageal hypersensitivity were compared with controls. The frequency, intensity, and duration of chest pain were assessed. Key Results One hundred and forty-three (75%) subjects had esophageal hypersensitivity and 46 (25%) had normal sensitivity. Typical chest pain was reproduced in 105/143 (74%) subjects. Subjects with hypersensitivity demonstrated larger cross-sectional area (P < 0.001), decreased esophageal wall strain (P < 0.001) and distensibility (P < 0.001), and lower thresholds for perception (P < 0.01), discomfort (P < 0.01), and pain (P < 0.01) compared to those without hypersensitivity or healthy controls. Chest pain scores (mean ± SD) for frequency, intensity and duration were 2.5 ± 0.3, 2.2 ± 0.2, and 2.2 ± 0.2, respectively, and were similar between the two patient groups. Conclusions & Inferences Seventy-five per cent of subjects with FCP demonstrate esophageal hypersensitivity. Visceral hyperalgesia and sensori-motor dysfunction of the esophagus play a key role in the pathogenesis of chest pain.

KW - Balloon distension test

KW - Esophagus

KW - Functional chest pain

KW - Sensory and biomechanical properties

UR - http://www.scopus.com/inward/record.url?scp=77950673444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950673444&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2982.2009.01451.x

DO - 10.1111/j.1365-2982.2009.01451.x

M3 - Article

C2 - 20067548

AN - SCOPUS:77950673444

VL - 22

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 5

ER -