Invited commentary: Genetic variants and individual- and societal-level risk factors

Research output: Contribution to journalComment/debate

4 Scopus citations

Abstract

Over the past decade, leading epidemiologists have noted the importance of social factors in studying and understanding the distribution and determinants of disease in human populations; but to what extent are epidemiologic studies integrating genetic information and other biologic variables with information about individual-level risk factors and group-level or societal factors related to the broader residential, behavioral, or cultural context? There remains a need to consider ways to integrate genetic information with social and contextual information in epidemiologic studies, partly to combat the overemphasis on the importance of genetic factors as determinants of disease in human populations. Even in genome-wide association studies of coronary heart disease and other common complex diseases, only a small proportion of heritability is explained by the genetic variants identified to date. It is possible that familial clustering due to genetic factors has been overestimated and that important environmental or social influences (acting alone or in combination with genetic variants) have been overlooked. The accompanying article by Bressler et al. (Am J Epidemiol. 2010;171(1):14-23) highlights some of these important issues.

Original languageEnglish (US)
Pages (from-to)24-26
Number of pages3
JournalAmerican journal of epidemiology
Volume171
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • Coronary disease
  • Genetic variation
  • Genetics
  • Genomics
  • Heart diseases
  • Myocardial infarction
  • Polymorphism, single nucleotide

ASJC Scopus subject areas

  • Epidemiology

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