Is abnormal glucose tolerance in antipsychotic-naïve patients with nonaffective psychosis confounded by poor health habits?

Brian Kirkpatrick, Brian J Miller, Clemente Garcia-Rizo, Emilio Fernandez-Egea, Miguel Bernardo

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Some but not all previous studies have found abnormal glucose tolerance or fasting glucose concentrations in antipsychotic-naïve patients with nonaffective psychosis. Our finding of abnormal glucose tolerance in patients with nonaffective psychosis could not be attributed to confounding by age, ethnicity, gender, smoking, socioeconomic status (SES), hypercortisolemia, or body mass index (BMI). However, other factors merit consideration as potential confounders of this association. Methods: An extended sample of newly diagnosed, antipsychotic-naive patients with schizophrenia and related disorders and matched controls were administered an oral glucose tolerance test. Confounding factors related to diet, self-care/access to care, and drug abuse were evaluated. Results: After accounting for the variance due to age, ethnicity, gender, smoking, SES, morning cortisol concentrations, BMI (or waist-hip ratio), our previous finding of abnormal glucose tolerance in these patients was confirmed. This difference could not be attributed to confounding by substance abuse; blood concentrations of vitamin B12, folate, or homocysteine; aerobic conditioning as measured by resting heart rate; or duration of untreated psychosis. Discussion: These results provide further evidence that people with schizophrenia and related disorders have abnormal glucose tolerance and an increased risk of diabetes prior to antipsychotic treatment and independent of health habits and access to care. Other measures should also be examined.

Original languageEnglish (US)
Pages (from-to)280-284
Number of pages5
JournalSchizophrenia Bulletin
Volume38
Issue number2
DOIs
StatePublished - Mar 1 2012

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Psychotic Disorders
Antipsychotic Agents
Habits
Glucose
Health
Social Class
Substance-Related Disorders
Schizophrenia
Body Mass Index
Smoking
Health Services Accessibility
Waist-Hip Ratio
Homocysteine
Vitamin B 12
Glucose Tolerance Test
Self Care
Folic Acid
Hydrocortisone
Fasting
Heart Rate

Keywords

  • diabetes
  • diet
  • inflammation
  • schizophrenia
  • stress

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Is abnormal glucose tolerance in antipsychotic-naïve patients with nonaffective psychosis confounded by poor health habits? / Kirkpatrick, Brian; Miller, Brian J; Garcia-Rizo, Clemente; Fernandez-Egea, Emilio; Bernardo, Miguel.

In: Schizophrenia Bulletin, Vol. 38, No. 2, 01.03.2012, p. 280-284.

Research output: Contribution to journalArticle

Kirkpatrick, Brian ; Miller, Brian J ; Garcia-Rizo, Clemente ; Fernandez-Egea, Emilio ; Bernardo, Miguel. / Is abnormal glucose tolerance in antipsychotic-naïve patients with nonaffective psychosis confounded by poor health habits?. In: Schizophrenia Bulletin. 2012 ; Vol. 38, No. 2. pp. 280-284.
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