Is nuclear factor-κB a good treatment target in brain ischemia/reperfusion injury?

James Edwin Carroll, David C Hess, Eugene F. Howard, William D Hill

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Nuclear factor-κB (NF-κB) is a transcription factor which resides in its unactivated form in the cytoplasm. Following activation subsequent to cerebral ischemia and reperfusion injury, NF-κB acts on genes for cytokines, adhesion molecules, nitric oxide synthase, cyclooxygenase-2, metalloproteinase-9, and perhaps apoptotic genes. These genes have a variety of positive and negative influences on the outcome of brain injury. The effect of manipulation of NF-κB needs to be examined critically, as it pertains to these reactive genes. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
JournalNeuroReport
Volume11
Issue number9
StatePublished - Jun 26 2000

Keywords

  • Apoptosis
  • Cell adhesion molecules
  • Endothelium
  • Nuclear factor- κB
  • Reperfusion injury

ASJC Scopus subject areas

  • Neuroscience(all)

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