TY - JOUR
T1 - Is Variant Angina the Coronary Manifestation of a Generalized Vasospastic Disorder?
AU - Miller, Douglas
AU - Waters, David D.
AU - Warnica, Wayne
AU - Szlachcic, Jadwiga
AU - Kreeft, John
AU - Théroux, Pierre
PY - 1981/3/26
Y1 - 1981/3/26
N2 - IN VARIANT angina, myocardial ischemia is caused by transient coronary-arterial spasm.1,2 Although altered adrenergic activity has been proposed as the cause of coronary spasm3,4 and high circulating thromboxane levels are found in patients with variant angina, 5 the true cause of the syndrome is unknown. The prodromal phase of migraine is caused by inappropriate vasoconstriction of cranial arteries, 6,7 and enzymatic markers of cerebral ischemia can be detected in the cerebrospinal fluid after an attack.8 As in variant angina, abnormal platelet function has been described in migraine.9,10 In spite of a variety of known triggering factors, the cause of migraine has not.
AB - IN VARIANT angina, myocardial ischemia is caused by transient coronary-arterial spasm.1,2 Although altered adrenergic activity has been proposed as the cause of coronary spasm3,4 and high circulating thromboxane levels are found in patients with variant angina, 5 the true cause of the syndrome is unknown. The prodromal phase of migraine is caused by inappropriate vasoconstriction of cranial arteries, 6,7 and enzymatic markers of cerebral ischemia can be detected in the cerebrospinal fluid after an attack.8 As in variant angina, abnormal platelet function has been described in migraine.9,10 In spite of a variety of known triggering factors, the cause of migraine has not.
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U2 - 10.1056/NEJM198103263041306
DO - 10.1056/NEJM198103263041306
M3 - Article
C2 - 7464885
AN - SCOPUS:0019463384
SN - 0028-4793
VL - 304
SP - 763
EP - 766
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -