Is Variant Angina the Coronary Manifestation of a Generalized Vasospastic Disorder?

Douglas Miller, David D. Waters, Wayne Warnica, Jadwiga Szlachcic, John Kreeft, Pierre Théroux

Research output: Contribution to journalArticlepeer-review

203 Scopus citations


IN VARIANT angina, myocardial ischemia is caused by transient coronary-arterial spasm.1,2 Although altered adrenergic activity has been proposed as the cause of coronary spasm3,4 and high circulating thromboxane levels are found in patients with variant angina, 5 the true cause of the syndrome is unknown. The prodromal phase of migraine is caused by inappropriate vasoconstriction of cranial arteries, 6,7 and enzymatic markers of cerebral ischemia can be detected in the cerebrospinal fluid after an attack.8 As in variant angina, abnormal platelet function has been described in migraine.9,10 In spite of a variety of known triggering factors, the cause of migraine has not.

Original languageEnglish (US)
Pages (from-to)763-766
Number of pages4
JournalNew England Journal of Medicine
Issue number13
StatePublished - Mar 26 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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