Kinetics of fluid delivery from methylcellulose sponges

Steven E. Brooks, Martin L. Laird, Dennis M. Marcus, Maribeth H. Johnson, Jack I. Ramage, Keith Green

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: The authors quantitatively evaluate the kinetics of fluid transfer from microsurgical sponges in a laboratory model to understand the kinetics of mitomycin C (MMC) delivery. Methods: The amount of fluid transferred from soaked methylcellulose (Weck-cel, Weck Inc., Durham, NC, U.S.A.) sponges to small pieces of hydrated or dry filter paper used to simulate episcleral tissue and Tenon fascia was measured as a function of time, sponge size, hydration status of the filter paper, and technique of sponge application. Results: The time course of fluid delivery from methylcellulose sponges to filter paper was nonlinear and characterized by a rapid delivery phase over the first 15 to 30 seconds, followed by a slow phase extending to at least 5 minutes. Sponge size and baseline hydration of the paper significantly influenced the rate and amount of fluid delivered, as did replacing the sponge every minute with a new sponge. Conclusion: The transfer of fluid from a microsurgical sponge displays nonlinear kinetics, with the majority of delivery occurring in the first 15 to 30 seconds. Sponge size, hydration of the recipient tissue, and technique of sponge application are significant variables influencing the amount of fluid, and therefore mitomycin C, delivered.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalJournal of Glaucoma
Volume7
Issue number1
DOIs
StatePublished - Feb 1998

Keywords

  • Drug delivery
  • Glaucoma
  • Mitomycin C
  • Trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology

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    Brooks, S. E., Laird, M. L., Marcus, D. M., Johnson, M. H., Ramage, J. I., & Green, K. (1998). Kinetics of fluid delivery from methylcellulose sponges. Journal of Glaucoma, 7(1), 16-21. https://doi.org/10.1097/00061198-199802000-00004