Laboratory Evaluation of Spasmodic Dysphonia

Sammy Othman, Srihari Daggumati, Rohan Patel, Justin Ross, Robert T. Sataloff

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: To evaluate the utility of comprehensive laboratory evaluation in patients with spasmodic dysphonia (SD). Study Design: Retrospective chart review. Methods: A review of the medical records of 40 patients diagnosed with spasmodic dysphonia from 2009-2018 was preformed to evaluate abnormal test results that were significant when compared with abnormal results of the general population and for any other clinically relevant pathology. Results: Erythrocyte sedimentation rate, ceruloplasmin levels, and anti-AChR were found to be elevated at levels considered statistically significant (p <0.05). Furthermore, we found levels of cholesterol, thyroid-stimulating hormone (TSH), T3, fasting blood glucose, creatine kinase, immunoglobulin, antinuclear antibody (ANA), and alpha-fetoprotein (AFP) levels to be abnormal at a greater rate in our population, but these were not statistically significant. Workup revealed several underlying conditions including thyroid neoplasms, hypothyroidism, and laryngopharyngeal reflux. Additionally, brain MRI revealed age-related ischemic pathology in an elevated number of patients, but with no obvious clinical sequalae. Conclusion: There is an association between serological values and spasmodic dysphonia that can aid in diagnosing pathology, as well as establishing a directed workup. Additionally, our study shows the utility of comprehensive evaluation in identifying undetected disease.

Original languageEnglish (US)
Pages (from-to)934-939
Number of pages6
JournalJournal of Voice
Issue number6
StatePublished - Nov 2020
Externally publishedYes


  • Dystonia
  • Laboratory
  • Spasmodic dysphonia
  • Vocal fold dystonia
  • Vocal fold spasms
  • Work-up

ASJC Scopus subject areas

  • Otorhinolaryngology
  • LPN and LVN
  • Speech and Hearing


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