Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: A meta-analysis

Wen Sun, Yan Sheng, Yu Weng, Chun Xiao Xu, Susan E.I. Williams, Yu Tao Liu, Michael A. Hauser, R. Rand Allingham, Ming Juan Jin, Guang Di Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

AIM: To study the associations between lysyl oxidase-like 1 (LOXL1) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this st udy, we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk. METHODS: Published literature from PubMed and other databases were retrieved. All studies evaluating the association between LOXL1 polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model. RESULTS: Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each LOXL1 polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC vs CC: OR, 0.79, 95%CI: 0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT vs CC+CT: OR, 1.23, 95%CI: 1.01-1.50); however, these associations were not found in population-based subjects. CONCLUSION: This meta-analysis suggests that LOXL1 polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of LOXL1 polymorphisms with POAG risk in hospital-based populations await further investigation. Copyright International Journal of Ophthalmology Press.

Original languageEnglish (US)
Pages (from-to)550-556
Number of pages7
JournalInternational Journal of Ophthalmology
Volume7
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Protein-Lysine 6-Oxidase
Meta-Analysis
Population
Odds Ratio
Confidence Intervals
Primary Open Angle Glaucoma
Heterozygote
PubMed
Sample Size
Databases

Keywords

  • Gene polymorphism
  • Glaucoma
  • Lysyl oxidase-like 1
  • Meta-analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma : A meta-analysis. / Sun, Wen; Sheng, Yan; Weng, Yu; Xu, Chun Xiao; Williams, Susan E.I.; Liu, Yu Tao; Hauser, Michael A.; Allingham, R. Rand; Jin, Ming Juan; Chen, Guang Di.

In: International Journal of Ophthalmology, Vol. 7, No. 3, 2014, p. 550-556.

Research output: Contribution to journalArticle

Sun, Wen ; Sheng, Yan ; Weng, Yu ; Xu, Chun Xiao ; Williams, Susan E.I. ; Liu, Yu Tao ; Hauser, Michael A. ; Allingham, R. Rand ; Jin, Ming Juan ; Chen, Guang Di. / Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma : A meta-analysis. In: International Journal of Ophthalmology. 2014 ; Vol. 7, No. 3. pp. 550-556.
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abstract = "AIM: To study the associations between lysyl oxidase-like 1 (LOXL1) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this st udy, we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk. METHODS: Published literature from PubMed and other databases were retrieved. All studies evaluating the association between LOXL1 polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95{\%} confidence interval (CI) were calculated using random- or fixed-effects model. RESULTS: Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each LOXL1 polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC vs CC: OR, 0.79, 95{\%}CI: 0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT vs CC+CT: OR, 1.23, 95{\%}CI: 1.01-1.50); however, these associations were not found in population-based subjects. CONCLUSION: This meta-analysis suggests that LOXL1 polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of LOXL1 polymorphisms with POAG risk in hospital-based populations await further investigation. Copyright International Journal of Ophthalmology Press.",
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T1 - Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma

T2 - A meta-analysis

AU - Sun, Wen

AU - Sheng, Yan

AU - Weng, Yu

AU - Xu, Chun Xiao

AU - Williams, Susan E.I.

AU - Liu, Yu Tao

AU - Hauser, Michael A.

AU - Allingham, R. Rand

AU - Jin, Ming Juan

AU - Chen, Guang Di

PY - 2014

Y1 - 2014

N2 - AIM: To study the associations between lysyl oxidase-like 1 (LOXL1) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this st udy, we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk. METHODS: Published literature from PubMed and other databases were retrieved. All studies evaluating the association between LOXL1 polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model. RESULTS: Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each LOXL1 polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC vs CC: OR, 0.79, 95%CI: 0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT vs CC+CT: OR, 1.23, 95%CI: 1.01-1.50); however, these associations were not found in population-based subjects. CONCLUSION: This meta-analysis suggests that LOXL1 polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of LOXL1 polymorphisms with POAG risk in hospital-based populations await further investigation. Copyright International Journal of Ophthalmology Press.

AB - AIM: To study the associations between lysyl oxidase-like 1 (LOXL1) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this st udy, we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk. METHODS: Published literature from PubMed and other databases were retrieved. All studies evaluating the association between LOXL1 polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model. RESULTS: Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each LOXL1 polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC vs CC: OR, 0.79, 95%CI: 0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT vs CC+CT: OR, 1.23, 95%CI: 1.01-1.50); however, these associations were not found in population-based subjects. CONCLUSION: This meta-analysis suggests that LOXL1 polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of LOXL1 polymorphisms with POAG risk in hospital-based populations await further investigation. Copyright International Journal of Ophthalmology Press.

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KW - Glaucoma

KW - Lysyl oxidase-like 1

KW - Meta-analysis

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