Abstract
Objective: To summarize current findings relevant to the function of apolipoprotein A-II (apoA-II), a major protein component of high density lipoproteins (HDL). Study Selection: Studies relating to the structure, regulation and genetics of apoA-II are reviewed. These include studies of apoA-II expression in humans and mouse animal models. All studies cited were published between 1972 and 1993. Conclusions: Since its discovery over 20 years ago, apoA-II has been a protein in search of a function. In fact, it has often been stated that apoA-II has no major function in plasma lipoprotein metabolism. While it is clear that apoA-II does not serve an essential function in HDL metabolism, the evidence overwhelmingly indicates that apoA-II importantly influences HDL functional states and suggests strongly that apoA-II is likely to contribute to atherogenesis.
Original language | English (US) |
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Pages (from-to) | 453-459 |
Number of pages | 7 |
Journal | Canadian Journal of Cardiology |
Volume | 10 |
Issue number | 4 |
State | Published - 1994 |
Keywords
- Apolipoprotein A-II
- Atherosclerosis
- Genetics
- High density lipoproteins
- Transgenic mice
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine