Lentivirus as a potent and mechanistically distinct vector for genetic immunization

Yukai He, Louis D. Falo

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

T-cell-mediated immunity is critical for the prevention and control of a broad range of infectious diseases and human malignancies. Genetic immunization is a promising approach for the elicitation of T-cell immunity. Recombinant lentivectors are now being developed and evaluated as antigen delivery platforms for genetic immunization and immune engineering. Early results from studies utilizing lentivectors are promising. Third generation lentivectors have been engineered to improve biosafety and reduce antivector immune responses. The ability of third generation lentivectors to efficiently transduce non-dividing cells, including dendritic cells, suggests important advantages over other antigen delivery platforms. Studies suggest that immunization with lentivectors induces remarkably potent and durable primary and memory T-cell immunity. The combination of skin-targeted immunization and potentially unique mechanisms of immune induction likely contribute to the potent immunogenicity observed. Taken together, this accumulating evidence supports the ongoing development and clinical translation of lentivector-based genetic immunization strategies.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalCurrent Opinion in Molecular Therapeutics
Volume9
Issue number5
StatePublished - Oct 19 2007

Fingerprint

Genetic Vectors
Lentivirus
Immunization
T-Lymphocytes
Immunity
Antigens
Cellular Immunity
Dendritic Cells
Communicable Diseases
Skin
Neoplasms

Keywords

  • Antigen presentation
  • Dendritic cell
  • Genetic immunization
  • Lentivirus
  • Skin immune system
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery
  • Genetics(clinical)

Cite this

Lentivirus as a potent and mechanistically distinct vector for genetic immunization. / He, Yukai; Falo, Louis D.

In: Current Opinion in Molecular Therapeutics, Vol. 9, No. 5, 19.10.2007, p. 439-446.

Research output: Contribution to journalReview article

@article{601bceab4f204fcfb39e05bc80d9176e,
title = "Lentivirus as a potent and mechanistically distinct vector for genetic immunization",
abstract = "T-cell-mediated immunity is critical for the prevention and control of a broad range of infectious diseases and human malignancies. Genetic immunization is a promising approach for the elicitation of T-cell immunity. Recombinant lentivectors are now being developed and evaluated as antigen delivery platforms for genetic immunization and immune engineering. Early results from studies utilizing lentivectors are promising. Third generation lentivectors have been engineered to improve biosafety and reduce antivector immune responses. The ability of third generation lentivectors to efficiently transduce non-dividing cells, including dendritic cells, suggests important advantages over other antigen delivery platforms. Studies suggest that immunization with lentivectors induces remarkably potent and durable primary and memory T-cell immunity. The combination of skin-targeted immunization and potentially unique mechanisms of immune induction likely contribute to the potent immunogenicity observed. Taken together, this accumulating evidence supports the ongoing development and clinical translation of lentivector-based genetic immunization strategies.",
keywords = "Antigen presentation, Dendritic cell, Genetic immunization, Lentivirus, Skin immune system, Vaccine",
author = "Yukai He and Falo, {Louis D.}",
year = "2007",
month = "10",
day = "19",
language = "English (US)",
volume = "9",
pages = "439--446",
journal = "Current Opinion in Molecular Therapeutics",
issn = "1464-8431",
publisher = "Current Drugs Ltd.",
number = "5",

}

TY - JOUR

T1 - Lentivirus as a potent and mechanistically distinct vector for genetic immunization

AU - He, Yukai

AU - Falo, Louis D.

PY - 2007/10/19

Y1 - 2007/10/19

N2 - T-cell-mediated immunity is critical for the prevention and control of a broad range of infectious diseases and human malignancies. Genetic immunization is a promising approach for the elicitation of T-cell immunity. Recombinant lentivectors are now being developed and evaluated as antigen delivery platforms for genetic immunization and immune engineering. Early results from studies utilizing lentivectors are promising. Third generation lentivectors have been engineered to improve biosafety and reduce antivector immune responses. The ability of third generation lentivectors to efficiently transduce non-dividing cells, including dendritic cells, suggests important advantages over other antigen delivery platforms. Studies suggest that immunization with lentivectors induces remarkably potent and durable primary and memory T-cell immunity. The combination of skin-targeted immunization and potentially unique mechanisms of immune induction likely contribute to the potent immunogenicity observed. Taken together, this accumulating evidence supports the ongoing development and clinical translation of lentivector-based genetic immunization strategies.

AB - T-cell-mediated immunity is critical for the prevention and control of a broad range of infectious diseases and human malignancies. Genetic immunization is a promising approach for the elicitation of T-cell immunity. Recombinant lentivectors are now being developed and evaluated as antigen delivery platforms for genetic immunization and immune engineering. Early results from studies utilizing lentivectors are promising. Third generation lentivectors have been engineered to improve biosafety and reduce antivector immune responses. The ability of third generation lentivectors to efficiently transduce non-dividing cells, including dendritic cells, suggests important advantages over other antigen delivery platforms. Studies suggest that immunization with lentivectors induces remarkably potent and durable primary and memory T-cell immunity. The combination of skin-targeted immunization and potentially unique mechanisms of immune induction likely contribute to the potent immunogenicity observed. Taken together, this accumulating evidence supports the ongoing development and clinical translation of lentivector-based genetic immunization strategies.

KW - Antigen presentation

KW - Dendritic cell

KW - Genetic immunization

KW - Lentivirus

KW - Skin immune system

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=35348882155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35348882155&partnerID=8YFLogxK

M3 - Review article

C2 - 17932808

AN - SCOPUS:35348882155

VL - 9

SP - 439

EP - 446

JO - Current Opinion in Molecular Therapeutics

JF - Current Opinion in Molecular Therapeutics

SN - 1464-8431

IS - 5

ER -