Leptin, blood pressure, and aerobic capacity in women

Manning J. Sabatier, Kevin K. McCully, Elaina L. Marinik, Earl H. Schwark, Sara Haddow Liebel, Miriam Yvette Cortez-Cooper, Michael F. Bergeron, Gloria Sloan, Joseph Gerard Cannon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: In animals, the adipocyte-derived hormone leptin induces increased blood pressure centrally via the hypothalamus, and one study has reported that exercise training decreases hypothalamic leptin receptor expression. In humans, high circulating leptin concentrations are associated with high blood pressure, but the possible influence of physical activity or aerobic capacity on this association is unknown. Methods: Forty-two healthy women, 25-40 years of age, with diverse ranges of body fatness and aerobic capacities, were studied under basal resting conditions. Blood pressure (sphygmomanometry), arterial stiffness (pulse wave velocity (PWV)), percent body fat (dual energy X-ray absorptiometry), circulating concentrations of leptin, soluble leptin receptor (sLR) (enzyme-linked immunoassay), and nitric oxide (Griess reaction) were measured. Results: Serum leptin correlated with percent body fat (R2 = 0.74, P < 0.0001) but was not significantly associated with aerobic capacity. Blood pressure correlated positively with serum leptin concentrations and had a negative interaction with aerobic capacity for both systolic (overall model: R2 = 0.33, P = 0.002) and diastolic (R2 = 0.48, P < 0.0001) pressure. The relation between leptin and blood pressure was attributable solely to women with below-median aerobic capacity even though their body fat percentages and leptin concentrations were similar to those of women above the median. The results could not be attributed to differences in peripheral factors such as sLR or nitric oxide concentrations or to differences in arterial stiffness determined by aortic PWV. Conclusions: Circulating leptin concentrations are related to body fatness, but the hypertensive influence of leptin is modified by physical fitness.

Original languageEnglish (US)
Pages (from-to)1245-1250
Number of pages6
JournalAmerican journal of hypertension
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2008

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Leptin
Blood Pressure
Leptin Receptors
Adipose Tissue
Pulse Wave Analysis
Vascular Stiffness
Nitric Oxide
Exercise
Physical Fitness
Photon Absorptiometry
Serum
Immunoenzyme Techniques
Adipocytes
Hypothalamus
Hormones
Hypertension
Pressure

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Sabatier, M. J., McCully, K. K., Marinik, E. L., Schwark, E. H., Liebel, S. H., Cortez-Cooper, M. Y., ... Cannon, J. G. (2008). Leptin, blood pressure, and aerobic capacity in women. American journal of hypertension, 21(11), 1245-1250. https://doi.org/10.1038/ajh.2008.254

Leptin, blood pressure, and aerobic capacity in women. / Sabatier, Manning J.; McCully, Kevin K.; Marinik, Elaina L.; Schwark, Earl H.; Liebel, Sara Haddow; Cortez-Cooper, Miriam Yvette; Bergeron, Michael F.; Sloan, Gloria; Cannon, Joseph Gerard.

In: American journal of hypertension, Vol. 21, No. 11, 01.11.2008, p. 1245-1250.

Research output: Contribution to journalArticle

Sabatier, MJ, McCully, KK, Marinik, EL, Schwark, EH, Liebel, SH, Cortez-Cooper, MY, Bergeron, MF, Sloan, G & Cannon, JG 2008, 'Leptin, blood pressure, and aerobic capacity in women', American journal of hypertension, vol. 21, no. 11, pp. 1245-1250. https://doi.org/10.1038/ajh.2008.254
Sabatier MJ, McCully KK, Marinik EL, Schwark EH, Liebel SH, Cortez-Cooper MY et al. Leptin, blood pressure, and aerobic capacity in women. American journal of hypertension. 2008 Nov 1;21(11):1245-1250. https://doi.org/10.1038/ajh.2008.254
Sabatier, Manning J. ; McCully, Kevin K. ; Marinik, Elaina L. ; Schwark, Earl H. ; Liebel, Sara Haddow ; Cortez-Cooper, Miriam Yvette ; Bergeron, Michael F. ; Sloan, Gloria ; Cannon, Joseph Gerard. / Leptin, blood pressure, and aerobic capacity in women. In: American journal of hypertension. 2008 ; Vol. 21, No. 11. pp. 1245-1250.
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AU - Liebel, Sara Haddow

AU - Cortez-Cooper, Miriam Yvette

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