Abstract
The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25% in frontal cortex, 19% in the parietal region and 10% in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.
Original language | English (US) |
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Pages (from-to) | 62-68 |
Number of pages | 7 |
Journal | Electroencephalography and Clinical Neurophysiology |
Volume | 79 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1991 |
Keywords
- (Rat)
- Acetylcholine
- Choline acetyltransferase
- EEG
- Nucleus basalis
ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology