Lesions of nucleus basalis alter ChAT activity and EEG in rat frontal neocortex

Patty G Ray, W. J. Jackson

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25% in frontal cortex, 19% in the parietal region and 10% in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology
Volume79
Issue number1
DOIs
StatePublished - Jan 1 1991

Keywords

  • (Rat)
  • Acetylcholine
  • Choline acetyltransferase
  • EEG
  • Nucleus basalis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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