Lesions of nucleus basalis alter ChAT activity and EEG in rat frontal neocortex

Patty G Ray, W. J. Jackson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25% in frontal cortex, 19% in the parietal region and 10% in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology
Volume79
Issue number1
DOIs
StatePublished - Jan 1 1991

Fingerprint

Choline O-Acetyltransferase
Neocortex
Electroencephalography
Frontal Lobe
Parietal Lobe
Visual Cortex
Ibotenic Acid
Fourier Analysis
Artifacts
Control Groups

Keywords

  • (Rat)
  • Acetylcholine
  • Choline acetyltransferase
  • EEG
  • Nucleus basalis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Lesions of nucleus basalis alter ChAT activity and EEG in rat frontal neocortex. / Ray, Patty G; Jackson, W. J.

In: Electroencephalography and Clinical Neurophysiology, Vol. 79, No. 1, 01.01.1991, p. 62-68.

Research output: Contribution to journalArticle

@article{75243242d68345fdb2bf059c3428528b,
title = "Lesions of nucleus basalis alter ChAT activity and EEG in rat frontal neocortex",
abstract = "The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25{\%} in frontal cortex, 19{\%} in the parietal region and 10{\%} in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.",
keywords = "(Rat), Acetylcholine, Choline acetyltransferase, EEG, Nucleus basalis",
author = "Ray, {Patty G} and Jackson, {W. J.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1016/0013-4694(91)90157-Y",
language = "English (US)",
volume = "79",
pages = "62--68",
journal = "Electroencephalography and Clinical Neurophysiology",
issn = "0013-4694",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Lesions of nucleus basalis alter ChAT activity and EEG in rat frontal neocortex

AU - Ray, Patty G

AU - Jackson, W. J.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25% in frontal cortex, 19% in the parietal region and 10% in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.

AB - The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25% in frontal cortex, 19% in the parietal region and 10% in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.

KW - (Rat)

KW - Acetylcholine

KW - Choline acetyltransferase

KW - EEG

KW - Nucleus basalis

UR - http://www.scopus.com/inward/record.url?scp=0025834568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025834568&partnerID=8YFLogxK

U2 - 10.1016/0013-4694(91)90157-Y

DO - 10.1016/0013-4694(91)90157-Y

M3 - Article

C2 - 1713553

AN - SCOPUS:0025834568

VL - 79

SP - 62

EP - 68

JO - Electroencephalography and Clinical Neurophysiology

JF - Electroencephalography and Clinical Neurophysiology

SN - 0013-4694

IS - 1

ER -