Lessons from the gene expression pattern of the rat zona glomerulosa

Koshiro Nishimoto, William E. Rainey, Wendy B. Bollag, Tsugio Seki

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

We recently identified hundreds of transcripts with differential expression in rat zona glomerulosa (zG) and zona fasciculata. Although the genes up-regulated in the zG may be playing important roles in aldosterone production, the relationship between most of these genes and aldosterone production has not been uncovered. Because aldosterone, in the presence of a high sodium diet, is now considered a significant cardiovascular risk factor, in this review we performed gene ontology and pathway analyses on the same microarray data to better define the genes that may influence zG function. Overall, we identified a number of genes that may be involved in aldosterone production through transforming growth factor β (TGF-β), WNT, calcium, potassium, and ACTH signaling pathways. The list of genes we present in the current report may become an important tool for researchers working on primary aldosteronism and aldosterone-related cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume371
Issue number1-2
DOIs
StatePublished - May 22 2013

Keywords

  • Adrenal gland
  • Aldosterone
  • Gene ontology
  • Pathway analysis
  • Transcriptome
  • Zona glomerulosa

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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