Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents

Vasiliki Lagou, Gaifen Liu, Haidong Zhu, Inger S. Stallmann-Jorgensen, Bernard Gutin, Yanbin Dong, Harold Snieder

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of the study is to investigate the influence of and interaction between lifestyle behaviors (diet and physical activity (PA)) and single-nucleotide polymorphisms (SNPs) in obesity-candidate genes (ADRB2, APOB and NOS3) on general and central adiposity. Six-hundred-and-twenty-one European-American (EA) and African-American (AA) youths aged 13-19 years were classified by ethnicity (49% AA), gender (45% male), and socioeconomic status (SES). PA and dietary intake with up to seven 24-h recalls were reported for all subjects. Percent body fat (%BF) was measured by dual-energy X-ray absorptiometry, visceral adipose tissue (VAT), and subcutaneous abdominal adipose tissue (SAAT) by magnetic resonance imaging. Reported energy intake (EI) and vigorous PA (VPA) were negative predictors of %BF and SAAT. Carriers of the NOS3 Asp298 allele had higher %BF only in the presence of an adverse environment (low SES). Compared to the most common NOS3 haplotype, homozygotes for haplotype A-non4r-Asp had 6.1% higher %BF. Significant interactions were revealed between the ADRB2 Arg16Gly SNP and VPA on VAT, SAAT and waist circumference (WC) such that Gly16 homozygotes may benefit less from increased VPA to reduce their weight. Genetic susceptibility to increased general and central adiposity is dependent on several factors, such as SES and vigorous exercise. Improved understanding of the joint effect of genes and lifestyle on adiposity will offer new insights into obesity and may provide new avenues for personalized prevention and treatment.

Original languageEnglish (US)
Pages (from-to)595-603
Number of pages9
JournalObesity
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

Adiposity
Abdominal Subcutaneous Fat
Social Class
African Americans
Life Style
Exercise
Intra-Abdominal Fat
Homozygote
Haplotypes
Single Nucleotide Polymorphism
Obesity
Photon Absorptiometry
Waist Circumference
Genetic Predisposition to Disease
Energy Intake
Genes
Adipose Tissue
Alleles
Magnetic Resonance Imaging
Diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents. / Lagou, Vasiliki; Liu, Gaifen; Zhu, Haidong; Stallmann-Jorgensen, Inger S.; Gutin, Bernard; Dong, Yanbin; Snieder, Harold.

In: Obesity, Vol. 19, No. 3, 01.03.2011, p. 595-603.

Research output: Contribution to journalArticle

Lagou, Vasiliki ; Liu, Gaifen ; Zhu, Haidong ; Stallmann-Jorgensen, Inger S. ; Gutin, Bernard ; Dong, Yanbin ; Snieder, Harold. / Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents. In: Obesity. 2011 ; Vol. 19, No. 3. pp. 595-603.
@article{d776186ab5514595b320f174fc12a89d,
title = "Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents",
abstract = "The aim of the study is to investigate the influence of and interaction between lifestyle behaviors (diet and physical activity (PA)) and single-nucleotide polymorphisms (SNPs) in obesity-candidate genes (ADRB2, APOB and NOS3) on general and central adiposity. Six-hundred-and-twenty-one European-American (EA) and African-American (AA) youths aged 13-19 years were classified by ethnicity (49{\%} AA), gender (45{\%} male), and socioeconomic status (SES). PA and dietary intake with up to seven 24-h recalls were reported for all subjects. Percent body fat ({\%}BF) was measured by dual-energy X-ray absorptiometry, visceral adipose tissue (VAT), and subcutaneous abdominal adipose tissue (SAAT) by magnetic resonance imaging. Reported energy intake (EI) and vigorous PA (VPA) were negative predictors of {\%}BF and SAAT. Carriers of the NOS3 Asp298 allele had higher {\%}BF only in the presence of an adverse environment (low SES). Compared to the most common NOS3 haplotype, homozygotes for haplotype A-non4r-Asp had 6.1{\%} higher {\%}BF. Significant interactions were revealed between the ADRB2 Arg16Gly SNP and VPA on VAT, SAAT and waist circumference (WC) such that Gly16 homozygotes may benefit less from increased VPA to reduce their weight. Genetic susceptibility to increased general and central adiposity is dependent on several factors, such as SES and vigorous exercise. Improved understanding of the joint effect of genes and lifestyle on adiposity will offer new insights into obesity and may provide new avenues for personalized prevention and treatment.",
author = "Vasiliki Lagou and Gaifen Liu and Haidong Zhu and Stallmann-Jorgensen, {Inger S.} and Bernard Gutin and Yanbin Dong and Harold Snieder",
year = "2011",
month = "3",
day = "1",
doi = "10.1038/oby.2010.224",
language = "English (US)",
volume = "19",
pages = "595--603",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents

AU - Lagou, Vasiliki

AU - Liu, Gaifen

AU - Zhu, Haidong

AU - Stallmann-Jorgensen, Inger S.

AU - Gutin, Bernard

AU - Dong, Yanbin

AU - Snieder, Harold

PY - 2011/3/1

Y1 - 2011/3/1

N2 - The aim of the study is to investigate the influence of and interaction between lifestyle behaviors (diet and physical activity (PA)) and single-nucleotide polymorphisms (SNPs) in obesity-candidate genes (ADRB2, APOB and NOS3) on general and central adiposity. Six-hundred-and-twenty-one European-American (EA) and African-American (AA) youths aged 13-19 years were classified by ethnicity (49% AA), gender (45% male), and socioeconomic status (SES). PA and dietary intake with up to seven 24-h recalls were reported for all subjects. Percent body fat (%BF) was measured by dual-energy X-ray absorptiometry, visceral adipose tissue (VAT), and subcutaneous abdominal adipose tissue (SAAT) by magnetic resonance imaging. Reported energy intake (EI) and vigorous PA (VPA) were negative predictors of %BF and SAAT. Carriers of the NOS3 Asp298 allele had higher %BF only in the presence of an adverse environment (low SES). Compared to the most common NOS3 haplotype, homozygotes for haplotype A-non4r-Asp had 6.1% higher %BF. Significant interactions were revealed between the ADRB2 Arg16Gly SNP and VPA on VAT, SAAT and waist circumference (WC) such that Gly16 homozygotes may benefit less from increased VPA to reduce their weight. Genetic susceptibility to increased general and central adiposity is dependent on several factors, such as SES and vigorous exercise. Improved understanding of the joint effect of genes and lifestyle on adiposity will offer new insights into obesity and may provide new avenues for personalized prevention and treatment.

AB - The aim of the study is to investigate the influence of and interaction between lifestyle behaviors (diet and physical activity (PA)) and single-nucleotide polymorphisms (SNPs) in obesity-candidate genes (ADRB2, APOB and NOS3) on general and central adiposity. Six-hundred-and-twenty-one European-American (EA) and African-American (AA) youths aged 13-19 years were classified by ethnicity (49% AA), gender (45% male), and socioeconomic status (SES). PA and dietary intake with up to seven 24-h recalls were reported for all subjects. Percent body fat (%BF) was measured by dual-energy X-ray absorptiometry, visceral adipose tissue (VAT), and subcutaneous abdominal adipose tissue (SAAT) by magnetic resonance imaging. Reported energy intake (EI) and vigorous PA (VPA) were negative predictors of %BF and SAAT. Carriers of the NOS3 Asp298 allele had higher %BF only in the presence of an adverse environment (low SES). Compared to the most common NOS3 haplotype, homozygotes for haplotype A-non4r-Asp had 6.1% higher %BF. Significant interactions were revealed between the ADRB2 Arg16Gly SNP and VPA on VAT, SAAT and waist circumference (WC) such that Gly16 homozygotes may benefit less from increased VPA to reduce their weight. Genetic susceptibility to increased general and central adiposity is dependent on several factors, such as SES and vigorous exercise. Improved understanding of the joint effect of genes and lifestyle on adiposity will offer new insights into obesity and may provide new avenues for personalized prevention and treatment.

UR - http://www.scopus.com/inward/record.url?scp=79952002660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952002660&partnerID=8YFLogxK

U2 - 10.1038/oby.2010.224

DO - 10.1038/oby.2010.224

M3 - Article

VL - 19

SP - 595

EP - 603

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 3

ER -