Linkage of a gene for dominant non-syndromic deafness to chromosome 19

Achih H. Chen; Li Ni; Kunihiro Fukushima; Jacquie Marietta; Marsha O'neill; Paul Coucke; Patrick Willems; Richard J.H. Smith

doi:10.1093/hmg/4.6.1073

Linkage of a gene for dominant non-syndromic deafness to chromosome 19

Achih H. Chen, Li Ni, Kunihiro Fukushima, Jacquie Marietta, Marsha O'neill, Paul Coucke, Patrick Willems, Richard J.H. Smith

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Inherited hearing impairment can occur either in the presence of other clinical features (syndromic hearing loss, SHL) or in isolation (non-syndromic hearing loss, NSHL). The latter is more common and is highly heterogeneous. To date, six NSHL loci have been mapped. We report the identification of a seventh locus (DFNA4) on chromosome 19q13 and suggest DM kinase as a possible candidate gene.

Original language	English (US)
Pages (from-to)	1073-1076
Number of pages	4
Journal	Human Molecular Genetics
Volume	4
Issue number	6
DOIs	https://doi.org/10.1093/hmg/4.6.1073
State	Published - Jun 1995
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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@article{dc659091ab624279a253d0f304e94ee1,

title = "Linkage of a gene for dominant non-syndromic deafness to chromosome 19",

abstract = "Inherited hearing impairment can occur either in the presence of other clinical features (syndromic hearing loss, SHL) or in isolation (non-syndromic hearing loss, NSHL). The latter is more common and is highly heterogeneous. To date, six NSHL loci have been mapped. We report the identification of a seventh locus (DFNA4) on chromosome 19q13 and suggest DM kinase as a possible candidate gene.",

author = "Chen, {Achih H.} and Li Ni and Kunihiro Fukushima and Jacquie Marietta and Marsha O'neill and Paul Coucke and Patrick Willems and Smith, {Richard J.H.}",

note = "Funding Information: We are grateful to the described family whose interest made this work possible. The mapping of DFNA4 was supported in part by funds from the Simon and Louise Henderson Foundation.",

year = "1995",

month = jun,

doi = "10.1093/hmg/4.6.1073",

language = "English (US)",

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T1 - Linkage of a gene for dominant non-syndromic deafness to chromosome 19

AU - Chen, Achih H.

AU - Ni, Li

AU - Fukushima, Kunihiro

AU - Marietta, Jacquie

AU - O'neill, Marsha

AU - Coucke, Paul

AU - Willems, Patrick

AU - Smith, Richard J.H.

N1 - Funding Information: We are grateful to the described family whose interest made this work possible. The mapping of DFNA4 was supported in part by funds from the Simon and Louise Henderson Foundation.

PY - 1995/6

Y1 - 1995/6

N2 - Inherited hearing impairment can occur either in the presence of other clinical features (syndromic hearing loss, SHL) or in isolation (non-syndromic hearing loss, NSHL). The latter is more common and is highly heterogeneous. To date, six NSHL loci have been mapped. We report the identification of a seventh locus (DFNA4) on chromosome 19q13 and suggest DM kinase as a possible candidate gene.

AB - Inherited hearing impairment can occur either in the presence of other clinical features (syndromic hearing loss, SHL) or in isolation (non-syndromic hearing loss, NSHL). The latter is more common and is highly heterogeneous. To date, six NSHL loci have been mapped. We report the identification of a seventh locus (DFNA4) on chromosome 19q13 and suggest DM kinase as a possible candidate gene.

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ER -

Linkage of a gene for dominant non-syndromic deafness to chromosome 19

Abstract

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