Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network

Research output: Contribution to journalArticle

Abstract

Objective: To study whether there is a difference in the prevalence of non–cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI). Design: A secondary analysis of data from three randomized clinical trials. Setting: Academic health centers. Patient(s): A total of 2,249 patients with normal uterine cavities. Interventions(s): None. Main Outcome Measure(s): The presence or absence of non–cavity-distorting fibroids. Result(s): Compared with women with UI, those with PCOS were younger, had a higher body mass index, and were more likely to be Hispanic or African American, with a lower percentage of previous conception and live birth, a higher percentage of current smokers, a lower percentage of current alcohol users, and higher total testosterone, fasting insulin, and homeostasis-model-assessment insulin resistance. The prevalence of women with non–cavity-distorting uterine fibroids was lower in women with PCOS than in those with UI (6.7% vs. 12.4%); this result held after patients were divided into Black and non-Black or into three different body mass index groups. After adjustment for all the other variables in the final model, patients with PCOS had a significantly lower prevalence of fibroids than those with UI (odds ratio 0.54). No differences in the prevalence of non–cavity-distorting fibroids with any dimensions ≥4 cm or the volume of the largest fibroid was found between the two groups. Conclusion(s): A lower prevalence of non–cavity-distorting uterine fibroids was found in infertile women with PCOS than in those with UI.

Original languageEnglish (US)
Pages (from-to)1011-1019.e1
JournalFertility and sterility
Volume111
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Polycystic Ovary Syndrome
Leiomyoma
Infertility
Body Mass Index
Live Birth
Hispanic Americans
African Americans
Insulin Resistance
Testosterone
Fasting
Homeostasis
Randomized Controlled Trials
Odds Ratio
Alcohols
Outcome Assessment (Health Care)
Insulin
Health

Keywords

  • PCOS
  • non–cavity-distorting fibroids
  • risk factor
  • unexplained infertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. / Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network.

In: Fertility and sterility, Vol. 111, No. 5, 01.05.2019, p. 1011-1019.e1.

Research output: Contribution to journalArticle

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network 2019, 'Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility', Fertility and sterility, vol. 111, no. 5, pp. 1011-1019.e1. https://doi.org/10.1016/j.fertnstert.2019.01.020
Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network. Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. Fertility and sterility. 2019 May 1;111(5):1011-1019.e1. https://doi.org/10.1016/j.fertnstert.2019.01.020
Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network. / Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. In: Fertility and sterility. 2019 ; Vol. 111, No. 5. pp. 1011-1019.e1.
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abstract = "Objective: To study whether there is a difference in the prevalence of non–cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI). Design: A secondary analysis of data from three randomized clinical trials. Setting: Academic health centers. Patient(s): A total of 2,249 patients with normal uterine cavities. Interventions(s): None. Main Outcome Measure(s): The presence or absence of non–cavity-distorting fibroids. Result(s): Compared with women with UI, those with PCOS were younger, had a higher body mass index, and were more likely to be Hispanic or African American, with a lower percentage of previous conception and live birth, a higher percentage of current smokers, a lower percentage of current alcohol users, and higher total testosterone, fasting insulin, and homeostasis-model-assessment insulin resistance. The prevalence of women with non–cavity-distorting uterine fibroids was lower in women with PCOS than in those with UI (6.7{\%} vs. 12.4{\%}); this result held after patients were divided into Black and non-Black or into three different body mass index groups. After adjustment for all the other variables in the final model, patients with PCOS had a significantly lower prevalence of fibroids than those with UI (odds ratio 0.54). No differences in the prevalence of non–cavity-distorting fibroids with any dimensions ≥4 cm or the volume of the largest fibroid was found between the two groups. Conclusion(s): A lower prevalence of non–cavity-distorting uterine fibroids was found in infertile women with PCOS than in those with UI.",
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T1 - Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility

AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network

AU - Huang, Hao

AU - Kuang, Hongying

AU - Sun, Fangbai

AU - Diamond, Michael Peter

AU - Legro, Richard S.

AU - Coutifaris, Christos

AU - Alvero, Ruben

AU - Robinson, Randal D.

AU - Casson, Peter R.

AU - Christman, Gregory M.

AU - Hansen, Karl R.

AU - Santoro, Nanette

AU - Eisenberg, Esther

AU - Zhang, Heping

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N2 - Objective: To study whether there is a difference in the prevalence of non–cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI). Design: A secondary analysis of data from three randomized clinical trials. Setting: Academic health centers. Patient(s): A total of 2,249 patients with normal uterine cavities. Interventions(s): None. Main Outcome Measure(s): The presence or absence of non–cavity-distorting fibroids. Result(s): Compared with women with UI, those with PCOS were younger, had a higher body mass index, and were more likely to be Hispanic or African American, with a lower percentage of previous conception and live birth, a higher percentage of current smokers, a lower percentage of current alcohol users, and higher total testosterone, fasting insulin, and homeostasis-model-assessment insulin resistance. The prevalence of women with non–cavity-distorting uterine fibroids was lower in women with PCOS than in those with UI (6.7% vs. 12.4%); this result held after patients were divided into Black and non-Black or into three different body mass index groups. After adjustment for all the other variables in the final model, patients with PCOS had a significantly lower prevalence of fibroids than those with UI (odds ratio 0.54). No differences in the prevalence of non–cavity-distorting fibroids with any dimensions ≥4 cm or the volume of the largest fibroid was found between the two groups. Conclusion(s): A lower prevalence of non–cavity-distorting uterine fibroids was found in infertile women with PCOS than in those with UI.

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