Management of imatinib-resistant patients with chronic myeloid leukemia

Pavan Kumar Bhamidipati, Hagop Kantarjian, Jorge Cortes, A. Megan Cornelison, Elias Jabbour

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Since its approval in 2001 for frontline management of chronic myelogenous leukemia (CML), imatinib has proven to be very effective in achieving high remission rates and improving prognosis. However, up to 33% of patients will not achieve optimal response. This has led researchers to develop new second- and third-generation tyrosine kinase inhibitors. In this article, we review the mechanisms of resistance, recommendations for monitoring, assessment of milestones, and management options for patients with CML who are resistant to imatinib therapy. We further explain the potential pitfalls that can lead to unnecessary discontinuation, the prognosis of patients whose condition fails to respond to treatment, and the upcoming therapies.

Original languageEnglish (US)
Pages (from-to)103-117
Number of pages15
JournalTherapeutic Advances in Hematology
Volume4
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • CML
  • imatinib resistance
  • treatment
  • tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Hematology

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