Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens

F. Martin, A. M. Oliver, J. F. Kearney

Research output: Contribution to journalArticlepeer-review

708 Scopus citations

Abstract

The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.

Original languageEnglish (US)
Pages (from-to)617-629
Number of pages13
JournalImmunity
Volume14
Issue number5
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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