Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease

Scott M. Palmer, Lisa J. Robinson, Andrew Wang, James R Gossage, Thomas Bashore, Victor F. Tapson

Research output: Contribution to journalArticle

172 Scopus citations


Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension associated with fibrotic occlusion of the smaller pulmonary veins. Although vasodilator therapy is effective in many patients with primary pulmonary hypertension, the role of vasodilators in PVOD is unclear because of concerns about precipitating pulmonary edema. Recently, however, there have been reports of successful therapy with oral vasodilators or intravenous administration of prostacyclin in patients with PVOD. In contrast, a patient with PVOD is described who developed acute pulmonary edema and respiratory failure during low-dose prostacyclin infusion, leading to death. This report suggests that vasodilators, especially prostacyclin, must be used with extreme caution in patients with known PVOD.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
Issue number1
StatePublished - Jan 1 1998
Externally publishedYes



  • Prostacyclin
  • Pulmonary hypertension
  • Pulmonary veno-occlusive disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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