Maternal separation during a specific postnatal time window prevents reinforcement of hippocampal long-term potentiation in adolescent rats

M. Gruss, K. Braun, Julietta Uta Frey, V. Korz

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In an attempt to develop an animal model to study the etiology of brain dysfunction in relation to early life experience, we tested the hypothesis that early-life stress during specific postnatal time windows affects long-term potentiation (LTP) reinforcement in adolescence. Male Wistar rat pups were stressed by separation from their dams for 24 h at postnatal day (PND) 4, 9, or 18. The animals were tested for reinforcement of LTP at adolescence (9 weeks old) by exposing them to a 2-min swim-stress. Here, we show that maternal separation during (at PND9) but not at the beginning (at PND4) or after (at PND18) the stress-hyporesponsive-period of the hypothalamic-pituitary-adrenal-axis impairs emotional LTP-reinforcement in adolescent animals. Thus, this in vivo model allows the investigation of physiological and pathophysiological emotional information processing at the cellular level in freely behaving adolescent animals.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNeuroscience
Volume152
Issue number1
DOIs
StatePublished - Mar 3 2008

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Long-Term Potentiation
Mothers
Life Change Events
Automatic Data Processing
Psychological Stress
Wistar Rats
Animal Models
Brain
Reinforcement (Psychology)

Keywords

  • LTP-reinforcement
  • SHRP
  • early stress
  • emotion
  • swim-stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maternal separation during a specific postnatal time window prevents reinforcement of hippocampal long-term potentiation in adolescent rats. / Gruss, M.; Braun, K.; Frey, Julietta Uta; Korz, V.

In: Neuroscience, Vol. 152, No. 1, 03.03.2008, p. 1-7.

Research output: Contribution to journalArticle

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