Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

Patricia R. Taylor, Christopher C. Paustian, Gary K. Koski, Daniel H. Zimmerman, Ken S. Rosenthal

Research output: Contribution to journalArticle

Abstract

LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalCellular Immunology
Volume262
Issue number1
DOIs
StatePublished - Feb 19 2010
Externally publishedYes

Fingerprint

Antigen Presentation
Interleukin-12
Dendritic Cells
Epitopes
Ligands
Monocytes
Peptides
gag Gene Products
beta 2-Microglobulin
Histocompatibility Antigens
Human Herpesvirus 1
Interleukin-4
Vaccines
HIV
Cytokines
T-Lymphocytes

Keywords

  • Dendritic cell
  • Human
  • LEAPS
  • Monocyte
  • Vaccine

ASJC Scopus subject areas

  • Immunology

Cite this

Taylor, P. R., Paustian, C. C., Koski, G. K., Zimmerman, D. H., & Rosenthal, K. S. (2010). Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens. Cellular Immunology, 262(1), 1-5. https://doi.org/10.1016/j.cellimm.2010.01.003

Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens. / Taylor, Patricia R.; Paustian, Christopher C.; Koski, Gary K.; Zimmerman, Daniel H.; Rosenthal, Ken S.

In: Cellular Immunology, Vol. 262, No. 1, 19.02.2010, p. 1-5.

Research output: Contribution to journalArticle

Taylor, PR, Paustian, CC, Koski, GK, Zimmerman, DH & Rosenthal, KS 2010, 'Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens', Cellular Immunology, vol. 262, no. 1, pp. 1-5. https://doi.org/10.1016/j.cellimm.2010.01.003
Taylor, Patricia R. ; Paustian, Christopher C. ; Koski, Gary K. ; Zimmerman, Daniel H. ; Rosenthal, Ken S. / Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens. In: Cellular Immunology. 2010 ; Vol. 262, No. 1. pp. 1-5.
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