Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

Patricia R. Taylor, Christopher C. Paustian, Gary K. Koski, Daniel H. Zimmerman, Ken S. Rosenthal

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalCellular Immunology
Volume262
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Dendritic cell
  • Human
  • LEAPS
  • Monocyte
  • Vaccine

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens'. Together they form a unique fingerprint.

  • Cite this