Measurement of heritability of myocardial blood flow by positron emission tomography: The Twins Heart Study

Shaoyong Su, John Votaw, Tracy Faber, Durreshahwar Khan, J. Douglas Bremner, Jack Goldberg, Ken Nichols, Andrew Van Tosh, Viola Vaccarino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). Design: Cross-sectional twin study. Setting: General clinical research centre of a university hospital at Atlanta, USA. Patients: A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. Main outcome measures: All twins underwent imaging of MBF with PET 13NH 3 at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. Results: The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). Conclusions: For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.

Original languageEnglish (US)
Pages (from-to)495-499
Number of pages5
JournalHeart
Volume98
Issue number6
DOIs
StatePublished - Mar 1 2012

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Twin Studies
Positron-Emission Tomography
Adenosine
Dizygotic Twins
Cross-Sectional Studies
Outcome Assessment (Health Care)
Research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Su, S., Votaw, J., Faber, T., Khan, D., Bremner, J. D., Goldberg, J., ... Vaccarino, V. (2012). Measurement of heritability of myocardial blood flow by positron emission tomography: The Twins Heart Study. Heart, 98(6), 495-499. https://doi.org/10.1136/heartjnl-2011-301080

Measurement of heritability of myocardial blood flow by positron emission tomography : The Twins Heart Study. / Su, Shaoyong; Votaw, John; Faber, Tracy; Khan, Durreshahwar; Bremner, J. Douglas; Goldberg, Jack; Nichols, Ken; Van Tosh, Andrew; Vaccarino, Viola.

In: Heart, Vol. 98, No. 6, 01.03.2012, p. 495-499.

Research output: Contribution to journalArticle

Su, S, Votaw, J, Faber, T, Khan, D, Bremner, JD, Goldberg, J, Nichols, K, Van Tosh, A & Vaccarino, V 2012, 'Measurement of heritability of myocardial blood flow by positron emission tomography: The Twins Heart Study', Heart, vol. 98, no. 6, pp. 495-499. https://doi.org/10.1136/heartjnl-2011-301080
Su, Shaoyong ; Votaw, John ; Faber, Tracy ; Khan, Durreshahwar ; Bremner, J. Douglas ; Goldberg, Jack ; Nichols, Ken ; Van Tosh, Andrew ; Vaccarino, Viola. / Measurement of heritability of myocardial blood flow by positron emission tomography : The Twins Heart Study. In: Heart. 2012 ; Vol. 98, No. 6. pp. 495-499.
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AB - Objective: To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). Design: Cross-sectional twin study. Setting: General clinical research centre of a university hospital at Atlanta, USA. Patients: A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. Main outcome measures: All twins underwent imaging of MBF with PET 13NH 3 at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. Results: The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). Conclusions: For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.

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