Abstract
Objective: To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). Design: Cross-sectional twin study. Setting: General clinical research centre of a university hospital at Atlanta, USA. Patients: A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. Main outcome measures: All twins underwent imaging of MBF with PET 13NH 3 at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. Results: The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). Conclusions: For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 495-499 |
| Number of pages | 5 |
| Journal | Heart |
| Volume | 98 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 1 2012 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Measurement of heritability of myocardial blood flow by positron emission tomography : The Twins Heart Study. / Su, Shaoyong; Votaw, John; Faber, Tracy; Khan, Durreshahwar; Bremner, J. Douglas; Goldberg, Jack; Nichols, Ken; Van Tosh, Andrew; Vaccarino, Viola.
In: Heart, Vol. 98, No. 6, 01.03.2012, p. 495-499.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement of heritability of myocardial blood flow by positron emission tomography
T2 - The Twins Heart Study
AU - Su, Shaoyong
AU - Votaw, John
AU - Faber, Tracy
AU - Khan, Durreshahwar
AU - Bremner, J. Douglas
AU - Goldberg, Jack
AU - Nichols, Ken
AU - Van Tosh, Andrew
AU - Vaccarino, Viola
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Objective: To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). Design: Cross-sectional twin study. Setting: General clinical research centre of a university hospital at Atlanta, USA. Patients: A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. Main outcome measures: All twins underwent imaging of MBF with PET 13NH 3 at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. Results: The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). Conclusions: For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.
AB - Objective: To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). Design: Cross-sectional twin study. Setting: General clinical research centre of a university hospital at Atlanta, USA. Patients: A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. Main outcome measures: All twins underwent imaging of MBF with PET 13NH 3 at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. Results: The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). Conclusions: For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.
UR - http://www.scopus.com/inward/record.url?scp=84857448232&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857448232&partnerID=8YFLogxK
U2 - 10.1136/heartjnl-2011-301080
DO - 10.1136/heartjnl-2011-301080
M3 - Article
C2 - 22323242
AN - SCOPUS:84857448232
VL - 98
SP - 495
EP - 499
JO - Heart
JF - Heart
SN - 1355-6037
IS - 6
ER -