Mechanism of membrane stabilization by calcium in vascular smooth muscle.

R. C. Webb, D. F. Bohr

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

In this study we observed relaxation in helical strips of rat tail artery in response to high concentrations of calcium after contraction induced by 10(-7) g/ml norepinephrine. This action of calcium on vascular smooth muscle contraction is referred to as the "membrane-stabilizing effect" of calcium. The current study demonstrates that changes caused by many of the variables that alter this relaxation induced by calcium parallel changes in relaxation in response to potassium; both are attenuated by ouabain, low sodium, reduced temperature, and low potassium. Relaxation produced by manganese is not similarly affected. Because potassium has been shown to cause relaxation of vascular smooth muscle by increasing the activity of sodium-potassium ATPase, we conclude that the relaxation produced by high concentrations of calcium is dependent on the activity of sodium-potassium ATPase; that produced by manganese is not.

Original languageEnglish (US)
Pages (from-to)C227-32
Number of pages6
JournalThe American journal of physiology
Volume235
Issue number5
StatePublished - Nov 1 1978

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Vascular Smooth Muscle
Muscle
Stabilization
Calcium
Membranes
Sodium-Potassium-Exchanging ATPase
Potassium
Manganese
Ouabain
Muscle Contraction
Tail
Rats
Norepinephrine
Arteries
Sodium
Temperature

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

Mechanism of membrane stabilization by calcium in vascular smooth muscle. / Webb, R. C.; Bohr, D. F.

In: The American journal of physiology, Vol. 235, No. 5, 01.11.1978, p. C227-32.

Research output: Contribution to journalArticle

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