Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

G. J. Alangaden, B. N. Kreiswirth, A. Aouad, M. Khetarpal, F. R. Igno, S. L. Moghazeh, E. K. Manavathu, S. A. Lerner

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157 Scopus citations

Abstract

An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

Original languageEnglish (US)
Pages (from-to)1295-1297
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume42
Issue number5
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Alangaden, G. J., Kreiswirth, B. N., Aouad, A., Khetarpal, M., Igno, F. R., Moghazeh, S. L., Manavathu, E. K., & Lerner, S. A. (1998). Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 42(5), 1295-1297. https://doi.org/10.1128/aac.42.5.1295