Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

G. J. Alangaden, B. N. Kreiswirth, A. Aouad, M. Khetarpal, F. R. Igno, S. L. Moghazeh, E. K. Manavathu, S. A. Lerner

Research output: Contribution to journalArticle

156 Scopus citations


An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

Original languageEnglish (US)
Pages (from-to)1295-1297
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number5
StatePublished - Jan 1 1998


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Alangaden, G. J., Kreiswirth, B. N., Aouad, A., Khetarpal, M., Igno, F. R., Moghazeh, S. L., Manavathu, E. K., & Lerner, S. A. (1998). Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 42(5), 1295-1297.