Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

G. J. Alangaden, B. N. Kreiswirth, A. Aouad, M. Khetarpal, F. R. Igno, S. L. Moghazeh, E. K. Manavathu, S. A. Lerner

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

Original languageEnglish (US)
Pages (from-to)1295-1297
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume42
Issue number5
StatePublished - May 30 1998

Fingerprint

Kanamycin
Amikacin
Mycobacterium tuberculosis
Mutation
Kanamycin Resistance
Genes

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Alangaden, G. J., Kreiswirth, B. N., Aouad, A., Khetarpal, M., Igno, F. R., Moghazeh, S. L., ... Lerner, S. A. (1998). Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 42(5), 1295-1297.

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. / Alangaden, G. J.; Kreiswirth, B. N.; Aouad, A.; Khetarpal, M.; Igno, F. R.; Moghazeh, S. L.; Manavathu, E. K.; Lerner, S. A.

In: Antimicrobial Agents and Chemotherapy, Vol. 42, No. 5, 30.05.1998, p. 1295-1297.

Research output: Contribution to journalArticle

Alangaden, GJ, Kreiswirth, BN, Aouad, A, Khetarpal, M, Igno, FR, Moghazeh, SL, Manavathu, EK & Lerner, SA 1998, 'Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis', Antimicrobial Agents and Chemotherapy, vol. 42, no. 5, pp. 1295-1297.
Alangaden GJ, Kreiswirth BN, Aouad A, Khetarpal M, Igno FR, Moghazeh SL et al. Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 1998 May 30;42(5):1295-1297.
Alangaden, G. J. ; Kreiswirth, B. N. ; Aouad, A. ; Khetarpal, M. ; Igno, F. R. ; Moghazeh, S. L. ; Manavathu, E. K. ; Lerner, S. A. / Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. In: Antimicrobial Agents and Chemotherapy. 1998 ; Vol. 42, No. 5. pp. 1295-1297.
@article{0253e584bc2b4b91a6c4bddc4779f0bd,
title = "Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis",
abstract = "An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.",
author = "Alangaden, {G. J.} and Kreiswirth, {B. N.} and A. Aouad and M. Khetarpal and Igno, {F. R.} and Moghazeh, {S. L.} and Manavathu, {E. K.} and Lerner, {S. A.}",
year = "1998",
month = "5",
day = "30",
language = "English (US)",
volume = "42",
pages = "1295--1297",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "5",

}

TY - JOUR

T1 - Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

AU - Alangaden, G. J.

AU - Kreiswirth, B. N.

AU - Aouad, A.

AU - Khetarpal, M.

AU - Igno, F. R.

AU - Moghazeh, S. L.

AU - Manavathu, E. K.

AU - Lerner, S. A.

PY - 1998/5/30

Y1 - 1998/5/30

N2 - An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

AB - An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

UR - http://www.scopus.com/inward/record.url?scp=0031971408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031971408&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 1295

EP - 1297

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 5

ER -