Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

G. J. Alangaden; B. N. Kreiswirth; A. Aouad; M. Khetarpal; F. R. Igno; S. L. Moghazeh; E. K. Manavathu; S. A. Lerner

doi:10.1128/aac.42.5.1295

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

G. J. Alangaden, B. N. Kreiswirth, A. Aouad, M. Khetarpal, F. R. Igno, S. L. Moghazeh, E. K. Manavathu, S. A. Lerner

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

Original language	English (US)
Pages (from-to)	1295-1297
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	42
Issue number	5
DOIs	https://doi.org/10.1128/aac.42.5.1295
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/aac.42.5.1295

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title = "Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis",

abstract = "An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.",

author = "Alangaden, {G. J.} and Kreiswirth, {B. N.} and A. Aouad and M. Khetarpal and Igno, {F. R.} and Moghazeh, {S. L.} and Manavathu, {E. K.} and Lerner, {S. A.}",

year = "1998",

doi = "10.1128/aac.42.5.1295",

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T1 - Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

AU - Alangaden, G. J.

AU - Kreiswirth, B. N.

AU - Aouad, A.

AU - Khetarpal, M.

AU - Igno, F. R.

AU - Moghazeh, S. L.

AU - Manavathu, E. K.

AU - Lerner, S. A.

PY - 1998

Y1 - 1998

N2 - An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

AB - An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross- resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

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Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

Abstract

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