Mechanisms by which KATP channel openers produce acute and delayed cardioprotection

Yigang Wang, Husnain Khawaja Haider, Nauman Ahmad, Muhammad Ashraf

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Mitochondria are being increasingly studied for their critical role in cell survival. Multiple diverse signaling pathways have been shown to converge on the K+-sensitive ATP channels as the effectors of cytoprotection against necrosis and apoptosis. The role of potassium channel openers in regulation and transformation of cell membrane excitability, action potential and electrolyte transfer has been extensively studied. Cardiac mitoK ATP channels are the key effectors in cardioprotection during ischemic preconditioning, as yet with an undefined mechanism. They have been hypothesized to couple myocardial metabolism with membrane electrical activity and provide an excellent target for drug therapy. A number of KATP channel openers have been characterized for their beneficial effects on the myocardium against ischemic injury. This review updates recent progress in understanding the physiological role of KATP channels in cardiac protection induced by preconditioning and highlights relevant questions and controversies in the light of published data.

Original languageEnglish (US)
Pages (from-to)253-264
Number of pages12
JournalVascular Pharmacology
Volume42
Issue number5-6
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

Fingerprint

KATP Channels
Ischemic Preconditioning
Cytoprotection
Potassium Channels
Electrolytes
Action Potentials
Cell Survival
Myocardium
Mitochondria
Necrosis
Adenosine Triphosphate
Cell Membrane
Apoptosis
Drug Therapy
Membranes
Wounds and Injuries
mitochondrial K(ATP) channel

Keywords

  • Cardioprotection
  • K
  • K channel
  • Mitochondria

ASJC Scopus subject areas

  • Physiology
  • Molecular Medicine
  • Pharmacology

Cite this

Mechanisms by which KATP channel openers produce acute and delayed cardioprotection. / Wang, Yigang; Haider, Husnain Khawaja; Ahmad, Nauman; Ashraf, Muhammad.

In: Vascular Pharmacology, Vol. 42, No. 5-6, 01.04.2005, p. 253-264.

Research output: Contribution to journalReview article

Wang, Yigang ; Haider, Husnain Khawaja ; Ahmad, Nauman ; Ashraf, Muhammad. / Mechanisms by which KATP channel openers produce acute and delayed cardioprotection. In: Vascular Pharmacology. 2005 ; Vol. 42, No. 5-6. pp. 253-264.
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