Mechanisms of cisplatin nephrotoxicity

Ronald P. Miller, Raghu K. Tadagavadi, Ganesan Ramesh, William Brian Reeves

Research output: Contribution to journalReview article

627 Citations (Scopus)

Abstract

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatininduced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

Original languageEnglish (US)
Pages (from-to)2490-2518
Number of pages29
JournalToxins
Volume2
Issue number11
DOIs
StatePublished - Nov 1 2010

Fingerprint

Cisplatin
Kidney
Wounds and Injuries
Cell death
Cell Death
Epithelial Cells
Inflammation
Research
Neoplasms

Keywords

  • Apoptosis
  • Cisplatin
  • Cytokines
  • Dendritic cells
  • Inflammation
  • Kidney injury
  • Nephrotoxicity
  • Toll-like receptors

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Miller, R. P., Tadagavadi, R. K., Ramesh, G., & Reeves, W. B. (2010). Mechanisms of cisplatin nephrotoxicity. Toxins, 2(11), 2490-2518. https://doi.org/10.3390/toxins2112490

Mechanisms of cisplatin nephrotoxicity. / Miller, Ronald P.; Tadagavadi, Raghu K.; Ramesh, Ganesan; Reeves, William Brian.

In: Toxins, Vol. 2, No. 11, 01.11.2010, p. 2490-2518.

Research output: Contribution to journalReview article

Miller, RP, Tadagavadi, RK, Ramesh, G & Reeves, WB 2010, 'Mechanisms of cisplatin nephrotoxicity', Toxins, vol. 2, no. 11, pp. 2490-2518. https://doi.org/10.3390/toxins2112490
Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of cisplatin nephrotoxicity. Toxins. 2010 Nov 1;2(11):2490-2518. https://doi.org/10.3390/toxins2112490
Miller, Ronald P. ; Tadagavadi, Raghu K. ; Ramesh, Ganesan ; Reeves, William Brian. / Mechanisms of cisplatin nephrotoxicity. In: Toxins. 2010 ; Vol. 2, No. 11. pp. 2490-2518.
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