Mechanisms of p53-mediated apoptosis

Hanfei Ding, David E. Fisher

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.

Original languageEnglish (US)
Pages (from-to)83-98
Number of pages16
JournalCritical Reviews in Oncogenesis
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Keywords

  • Caspases
  • Programmed cell death
  • Tumor suppressors
  • Tumor therapy
  • Tumorigenesis

ASJC Scopus subject areas

  • Cancer Research

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