Mediators of the Effects of Gender on Uric Acid Nephrolithiasis

A Novel Application of Structural Equation Modeling

Hao Wei Chen, Yu Chen Chen, Frances Margaret Yang, Wen Jeng Wu, Ching Chia Li, Yong Yuan Chang, Yii Her Chou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Numerous epidemiological studies have shown that male patients with uric acid nephrolithiasis outnumber female patients. To our knowledge, no research exists evaluating the reasons gender affects the development of uric acid nephrolithiasis. We hereby used a novel application of structural equation modeling to analyze the mediators of the effects of gender on uric acid nephrolithiasis. In 1,098 patients with nephrolithiasis between 2012 and 2016, male gender was found to have a statistically significant positive indirect effect on the development of uric acid nephrolithiasis, which was mediated by lower urine pH (estimate: 0.010, standard error: 0.005, critical ratio: 2.135, 95% confidence interval: 0.002-0.023, P = 0.017), lower estimated glomerular filtration rate (estimate: 0.014, standard error: 0.005, critical ratio: 2.993, 95% confidence interval: 0.006-0.025, P < 0.001), and higher incidence rate of gout (estimate: 0.009, standard error: 0.005, critical ratio: 2.028, 95% confidence interval: 0.002-0.021, P = 0.009). We conclude that low urine pH, impaired renal function, and gout are the mediators of the effect of male gender on the development of uric acid nephrolithiasis. The survey, treatment, and follow-up of kidney diseases, acidic urine, and uric acid metabolism disorders should be considered in men with uric acid nephrolithiasis.

Original languageEnglish (US)
Article number6077
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Nephrolithiasis
Uric Acid
Gout
Urine
Confidence Intervals
Kidney Diseases
Glomerular Filtration Rate
Epidemiologic Studies
Kidney
Incidence
Research

ASJC Scopus subject areas

  • General

Cite this

Mediators of the Effects of Gender on Uric Acid Nephrolithiasis : A Novel Application of Structural Equation Modeling. / Chen, Hao Wei; Chen, Yu Chen; Yang, Frances Margaret; Wu, Wen Jeng; Li, Ching Chia; Chang, Yong Yuan; Chou, Yii Her.

In: Scientific Reports, Vol. 8, No. 1, 6077, 01.12.2018.

Research output: Contribution to journalArticle

Chen, Hao Wei ; Chen, Yu Chen ; Yang, Frances Margaret ; Wu, Wen Jeng ; Li, Ching Chia ; Chang, Yong Yuan ; Chou, Yii Her. / Mediators of the Effects of Gender on Uric Acid Nephrolithiasis : A Novel Application of Structural Equation Modeling. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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