Membership in genetic groups predicts Alzheimer disease

Elizabeth H. Corder, Rong Huang, Heather M. Cathcart, Irene S. Lanham, Ginny R. Parker, Danny Cheng, Suzanne H Smith, Shirley E. Poduslo

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3-GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TJ; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalRejuvenation Research
Volume9
Issue number1
DOIs
StatePublished - Mar 1 2006

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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    Corder, E. H., Huang, R., Cathcart, H. M., Lanham, I. S., Parker, G. R., Cheng, D., Smith, S. H., & Poduslo, S. E. (2006). Membership in genetic groups predicts Alzheimer disease. Rejuvenation Research, 9(1), 89-93. https://doi.org/10.1089/rej.2006.9.89