Membership in genetic groups predicts Alzheimer disease

Elizabeth H. Corder, Rong Huang, Heather M. Cathcart, Irene S. Lanham, Ginny R. Parker, Danny Cheng, Suzanne H Smith, Shirley E. Poduslo

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15 Scopus citations

Abstract

The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3-GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TJ; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalRejuvenation Research
Volume9
Issue number1
DOIs
Publication statusPublished - Mar 1 2006

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ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Corder, E. H., Huang, R., Cathcart, H. M., Lanham, I. S., Parker, G. R., Cheng, D., ... Poduslo, S. E. (2006). Membership in genetic groups predicts Alzheimer disease. Rejuvenation Research, 9(1), 89-93. https://doi.org/10.1089/rej.2006.9.89