TY - JOUR
T1 - Membrane glycolipids in stem cells
AU - Yu, Robert K.
AU - Suzuki, Yusuke
AU - Yanagisawa, Makoto
N1 - Funding Information:
This work was supported by USPHS Grants NS11853 , NS26994 , AG027199 and a grant from the Childrens’ Medical Research Foundation , Chicago, IL to R.K.Y.
PY - 2010/5
Y1 - 2010/5
N2 - Stem cells, such as embryonic stem cells, hematopoietic stem cells, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells, are undifferentiated cells that are endowed with a high potential for proliferation and the capacity for self-renewal with retention of pluri/multipotency to differentiate into their progenies. Recently, studies regarding the biological functions of glycolipids and cell surface microdomains (caveolae, lipid rafts, or glycolipid-enriched microdomains) in stem cells are emerging. In this review, we introduce the expression patterns of glycolipids and the functional roles of cell surface microdomains in stem cells.
AB - Stem cells, such as embryonic stem cells, hematopoietic stem cells, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells, are undifferentiated cells that are endowed with a high potential for proliferation and the capacity for self-renewal with retention of pluri/multipotency to differentiate into their progenies. Recently, studies regarding the biological functions of glycolipids and cell surface microdomains (caveolae, lipid rafts, or glycolipid-enriched microdomains) in stem cells are emerging. In this review, we introduce the expression patterns of glycolipids and the functional roles of cell surface microdomains in stem cells.
KW - Cancer stem cell
KW - Cell surface microdomain
KW - Embryonic stem cell
KW - Glycolipid
KW - Hematopoietic stem cell
KW - Mesenchymal stem cell
KW - Neural stem cell
UR - http://www.scopus.com/inward/record.url?scp=77951894345&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951894345&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2009.08.026
DO - 10.1016/j.febslet.2009.08.026
M3 - Review article
C2 - 19716368
AN - SCOPUS:77951894345
SN - 0014-5793
VL - 584
SP - 1694
EP - 1699
JO - FEBS Letters
JF - FEBS Letters
IS - 9
ER -
