TY - JOUR
T1 - Membrane Trafficking of G Protein-Coupled Receptors
AU - Tan, Christopher M.
AU - Brady, Ashley E.
AU - Nickols, Hilary Highfield
AU - Wang, Qin
AU - Limbird, Lee E.
PY - 2004
Y1 - 2004
N2 - G protein-coupled receptors (GPCRs) modulate diverse physiological and behavioral signaling pathways by virtue of changes in receptor activation and inactivation states. Functional changes in receptor properties include dynamic interactions with regulatory molecules and trafficking to various cellular compartments at various stages of the life cycle of a GPCR. This review focuses on trafficking of GPCRs to the cell surface, stabilization there, and agonist-regulated turnover. GPCR interactions with a variety of newly revealed partners also are reviewed with the intention of provoking further analysis of the relevance of these interactions in GPCR trafficking, signaling, or both. The disease consequences of mislocalization of GPCRs also are described.
AB - G protein-coupled receptors (GPCRs) modulate diverse physiological and behavioral signaling pathways by virtue of changes in receptor activation and inactivation states. Functional changes in receptor properties include dynamic interactions with regulatory molecules and trafficking to various cellular compartments at various stages of the life cycle of a GPCR. This review focuses on trafficking of GPCRs to the cell surface, stabilization there, and agonist-regulated turnover. GPCR interactions with a variety of newly revealed partners also are reviewed with the intention of provoking further analysis of the relevance of these interactions in GPCR trafficking, signaling, or both. The disease consequences of mislocalization of GPCRs also are described.
KW - Agonist-elicited endocytosis
KW - Protein-protein interactions
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U2 - 10.1146/annurev.pharmtox.44.101802.121558
DO - 10.1146/annurev.pharmtox.44.101802.121558
M3 - Review article
C2 - 14744258
AN - SCOPUS:1342344805
SN - 0362-1642
VL - 44
SP - 559
EP - 609
JO - Annual Review of Pharmacology and Toxicology
JF - Annual Review of Pharmacology and Toxicology
ER -