Metabolic causes and consequences of sleep disorders

Varsha Surendranath Taskar, James Stocks, David Shafer, Max Hirskowitz

Research output: Contribution to journalReview article

Abstract

In recent years, an increasing amount of evidence has emerged showing that metabolic disturbances influence sleep and that sleep deprivation adversely affects metabolism. Sleep restriction may impair glucose tolerance and alter leptin levels. Physiologically, sleep deprivation creates a misperception of inadequate caloric intake and potentiates development of the Metabolic Syndrome. Excessive daytime sleepiness (EDS) can be produced by sleep problems such as sleep apnea and has also been shown to have an increased prevalence in individuals with endocrine disorders. The interrelationships between sleep, sex hormones, thyroid disorders, and growth hormone regulation in patients with sleep disordered breathing (SDB) are outlined in the present review. Increased prevalence of SDB is seen in diabetes; moreover, glucose control improves upon treatment with continuous positive airway pressure. Sleepiness, however, is more prevalent in obesity even in the absence of SDB. Diabetes is also associated with both sleep onset and sleep maintenance insomnia. The circadian rhythmicity of hormones can impact sleep stages. Perturbation of the circadian clock (eg, in shift work or jet lag) can contribute toward the development of metabolic disorders. In the past, treatment of the underlying metabolic disturbance was considered the mainstay of therapy to improve sleep. However, recent thinking is that the reverse may also be true, ie, improving the sleep disturbance will favorably affect endocrine function.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalClinical Pulmonary Medicine
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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Sleep
Sleep Apnea Syndromes
Sleep Deprivation
Glucose
Circadian Clocks
Continuous Positive Airway Pressure
Sleep Wake Disorders
Sleep Stages
Sleep Initiation and Maintenance Disorders
Gonadal Steroid Hormones
Periodicity
Leptin
Energy Intake
Thyroid Hormones
Growth Hormone
Therapeutics
Obesity
Maintenance
Hormones

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Metabolic causes and consequences of sleep disorders. / Taskar, Varsha Surendranath; Stocks, James; Shafer, David; Hirskowitz, Max.

In: Clinical Pulmonary Medicine, Vol. 15, No. 1, 01.01.2008, p. 40-44.

Research output: Contribution to journalReview article

Taskar, Varsha Surendranath ; Stocks, James ; Shafer, David ; Hirskowitz, Max. / Metabolic causes and consequences of sleep disorders. In: Clinical Pulmonary Medicine. 2008 ; Vol. 15, No. 1. pp. 40-44.
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