Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats

Claudio Da Cunha, Benno Roozendaal, Almira Ivanova Vazdarjanova, James L. McGaugh

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Extensive evidence indicates that benzodiazepine receptors in the amygdala are involved in regulating memory consolidation. Recent findings indicate that many other drugs and hormones influence memory through selective activation of the basolateral amygdala nucleus (BLA). This experiment examined whether the memory-modulatory effect of flumazenil, a benzodiazepine receptor antagonist, selectively involves the BLA. Bilateral microinfusions of flumazenil (12 nmol in 0.2 μl) into the BLA of rats administered immediately after training in an inhibitory avoidance task significantly enhanced 48-h retention performance whereas infusions into the central nucleus were ineffective. These findings indicate that the BLA is selectively involved in mediating flumazenil's influence on memory storage and are thus consistent with extensive evidence indicating that the BLA is involved in regulating memory consolidation.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNeurobiology of Learning and Memory
Volume72
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Flumazenil
GABA-A Receptors
Amygdala
Memory Consolidation
Basolateral Nuclear Complex
Central Amygdaloid Nucleus
Hormones
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats. / Da Cunha, Claudio; Roozendaal, Benno; Vazdarjanova, Almira Ivanova; McGaugh, James L.

In: Neurobiology of Learning and Memory, Vol. 72, No. 1, 01.01.1999, p. 1-7.

Research output: Contribution to journalArticle

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