MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

Li Zhou, Jang June Park, Quanhui Zheng, Zheng Dong, Qingsheng Mi

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4 + CD25 + Foxp3 + regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.

Original languageEnglish (US)
Pages (from-to)380-387
Number of pages8
JournalCellular and Molecular Immunology
Volume8
Issue number5
DOIs
StatePublished - Sep 1 2011

Keywords

  • invariant natural killer T cells
  • microRNA
  • regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function'. Together they form a unique fingerprint.

  • Cite this