MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

Li Zhou, Jang June Park, Quanhui Zheng, Zheng Dong, Qingsheng Mi

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4 + CD25 + Foxp3 + regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.

Original languageEnglish (US)
Pages (from-to)380-387
Number of pages8
JournalCellular and Molecular Immunology
Volume8
Issue number5
DOIs
StatePublished - Sep 1 2011

Fingerprint

Regulatory T-Lymphocytes
MicroRNAs
Natural Killer T-Cells
Self Tolerance
Small Untranslated RNA
Immunity
Homeostasis
Genes

Keywords

  • invariant natural killer T cells
  • microRNA
  • regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function. / Zhou, Li; Park, Jang June; Zheng, Quanhui; Dong, Zheng; Mi, Qingsheng.

In: Cellular and Molecular Immunology, Vol. 8, No. 5, 01.09.2011, p. 380-387.

Research output: Contribution to journalReview article

Zhou, Li ; Park, Jang June ; Zheng, Quanhui ; Dong, Zheng ; Mi, Qingsheng. / MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function. In: Cellular and Molecular Immunology. 2011 ; Vol. 8, No. 5. pp. 380-387.
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