MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

Li Zhou; Jang June Park; Quanhui Zheng; Zheng Dong; Qingsheng Mi

doi:10.1038/cmi.2011.27

MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

Li Zhou, Jang June Park, Quanhui Zheng, Zheng Dong, Qingsheng Mi

Cellular Biology and Anatomy

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4 ⁺ CD25 ⁺ Foxp3 ⁺ regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.

Original language	English (US)
Pages (from-to)	380-387
Number of pages	8
Journal	Cellular and Molecular Immunology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/cmi.2011.27
State	Published - Sep 2011

Keywords

invariant natural killer T cells
microRNA
regulatory T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/cmi.2011.27

Cite this

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title = "MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function",

abstract = "MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4 + CD25 + Foxp3 + regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.",

keywords = "invariant natural killer T cells, microRNA, regulatory T cells",

author = "Li Zhou and Park, {Jang June} and Quanhui Zheng and Zheng Dong and Qingsheng Mi",

note = "Funding Information: This work was support in part by grants from the Juvenile Diabetes Research Foundation International and the Henry Ford Immunology Program startup.",

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AU - Zhou, Li

AU - Park, Jang June

AU - Zheng, Quanhui

AU - Dong, Zheng

AU - Mi, Qingsheng

N1 - Funding Information: This work was support in part by grants from the Juvenile Diabetes Research Foundation International and the Henry Ford Immunology Program startup.

PY - 2011/9

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AB - MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4 + CD25 + Foxp3 + regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.

KW - invariant natural killer T cells

KW - microRNA

KW - regulatory T cells

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MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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