MicroRNAs in extracellular vesicles protect kidney from ischemic injury: from endothelial to tubular epithelial

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.

Original languageEnglish (US)
Pages (from-to)1150-1152
Number of pages3
JournalKidney International
Volume90
Issue number6
DOIs
StatePublished - Dec 1 2016

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MicroRNAs
Exosomes
Kidney
Wounds and Injuries
Stem Cells
Phosphoric Monoester Hydrolases
Acute Kidney Injury
Endothelial Cells
Apoptosis
Therapeutics
Extracellular Vesicles

ASJC Scopus subject areas

  • Nephrology

Cite this

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abstract = "Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Vi{\~n}as et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.",
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AB - Extracellular vesicles from stem cells or progenitor cells are novel therapeutic systems for acute kidney injury. With exosomes (the smallest class of extracellular vesicles), Viñas et al. successfully rescued ischemic injured kidney. MicroRNA-486-5p, the crucial factor specifically delivered by exosomes to kidney, ameliorates the injury by targeting phosphatase and tensin homolog and inhibiting endothelial cell apoptosis. In this commentary, we discuss the potential underlying mechanism and the pivotal impact of their study on extracellular vesicle therapy.

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