Mitochondrial dynamics in diabetes

Yisang Yoon, Chad A. Galloway, Bong Sook Jhun, Tianzheng Yu

Research output: Contribution to journalReview article

111 Scopus citations

Abstract

Mitochondria are at the center of cellular energy metabolism and regulate cell life and death. The cell biological aspect of mitochondria, especially mitochondrial dynamics, has drawn much attention through implications in human pathology, including neurological disorders and metabolic diseases. Mitochondrial fission and fusion are the main processes governing the morphological plasticity and are controlled by multiple factors, including mechanochemical enzymes and accessory proteins. Emerging evidence suggests that mitochondrial dynamics plays an important role in metabolism-secretion coupling in pancreatic β-cells as well as complications of diabetes. This review describes an overview of mechanistic and functional aspects of mitochondrial fission and fusion, and comments on the recent advances connecting mitochondrial dynamics with diabetes and diabetic complications.

Original languageEnglish (US)
Pages (from-to)439-457
Number of pages19
JournalAntioxidants and Redox Signaling
Volume14
Issue number3
DOIs
StatePublished - Feb 1 2011

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ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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