TY - JOUR
T1 - Mitochondrial dysfunction in obesity-related kidney disease
T2 - a novel therapeutic target
AU - Tang, Chengyuan
AU - Cai, Juan
AU - Dong, Zheng
N1 - Publisher Copyright:
© 2016
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet–induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.
AB - Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet–induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.
UR - http://www.scopus.com/inward/record.url?scp=84994176237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994176237&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2016.07.045
DO - 10.1016/j.kint.2016.07.045
M3 - Comment/debate
C2 - 27742195
AN - SCOPUS:84994176237
SN - 0085-2538
VL - 90
SP - 930
EP - 933
JO - Kidney International
JF - Kidney International
IS - 5
ER -
