Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target

Chengyuan Tang, Juan Cai, Zheng Dong

Research output: Contribution to journalComment/debate

8 Scopus citations

Abstract

Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet–induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.

Original languageEnglish (US)
Pages (from-to)930-933
Number of pages4
JournalKidney International
Volume90
Issue number5
DOIs
StatePublished - Nov 1 2016

ASJC Scopus subject areas

  • Nephrology

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