Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target

Chengyuan Tang, Juan Cai, Zheng Dong

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Abstract

Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet–induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.

Original languageEnglish (US)
Pages (from-to)930-933
Number of pages4
JournalKidney International
Volume90
Issue number5
DOIs
StatePublished - Nov 1 2016

Fingerprint

Kidney Diseases
Mitochondria
Obesity
Antioxidants
Fats
Kidney
Lipids
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Mitochondrial dysfunction in obesity-related kidney disease : a novel therapeutic target. / Tang, Chengyuan; Cai, Juan; Dong, Zheng.

In: Kidney International, Vol. 90, No. 5, 01.11.2016, p. 930-933.

Research output: Contribution to journalComment/debate

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