Mitochondrial morphology-emerging role in bioenergetics

Chad A. Galloway, Hakjoo Lee, Yisang Yoon

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Dynamic change in mitochondrial shape is a cellular process mediated mainly by fission and fusion of mitochondria. Studies have shown that mitochondrial fission and fusion are directly and indirectly associated with mitochondrial maintenance, bioenergetic demand, and cell death. Changes in mitochondrial morphology are frequently observed in response to changes in the surrounding cellular milieu, such as metabolic flux, that influence cellular bioenergetics. Connections between morphological regulation and the bioenergetic status of mitochondria are emerging as reciprocally responsive processes, though the nature of the signaling remains to be defined. Given the pivotal role mitochondria play in cellular fate, tight regulation of fission and fusion is therefore critical to preserving normal cellular physiology. Here we describe recent advancements in the understanding of the mechanisms governing mitochondrial morphology and their emerging role in mitochondrial bioenergetics.

Original languageEnglish (US)
Pages (from-to)2218-2228
Number of pages11
JournalFree Radical Biology and Medicine
Volume53
Issue number12
DOIs
StatePublished - Dec 15 2012

Keywords

  • Bioenergetics
  • DLP1
  • Drp1
  • Fission
  • Free radicals
  • Fusion
  • GTPase
  • Mfn
  • Mitochondria
  • Mitochondrial dynamics
  • Mitochondrial morphology
  • OPA1
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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