Modeling functional dynamics of cortical gyri and sulci

Xi Jiang, Xiang Li, Jinglei Lv, Shijie Zhao, Shu Zhang, Wei Zhang, Tuo Zhang, Tianming Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Cortical gyrification is one of the most prominent features of human brain. A variety of studies in the brain mapping field have demonstrated the specific structural and functional differences between gyral and sulcal regions. However,previous studies of gyri/sulci function analysis based on the fMRI data assume the temporal stationarity over the entire fMRI scan,while the possible temporal dynamics of gyri/sulci function is largely unknown. We present a computational framework to model the functional dynamics of cortical gyri and sulci based on task fMRI data. Specifically,the whole-brain fMRI signals’ temporal segments are derived via the sliding time window approach. The spatial overlap patterns among functional networks (SOPFNs),which are crucial for characterizing brain functions,are then measured within each time window via a group-wise sparse representation approach. Finally,the temporal dynamics of SOPFNs distribution on gyral/sulcal regions across all time windows are assessed. Experimental results based on the publicly released Human Connectome Project task fMRI data demonstrated that the proposed framework identified meaningful temporal dynamics difference of the SOPFNs distribution between gyral and sulcal regions which are reproducible across different subjects and task fMRI datasets. Our results provide novel understanding of functional dynamics mechanisms of human cerebral cortex.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings
EditorsSebastian Ourselin, Leo Joskowicz, Mert R. Sabuncu, William Wells, Gozde Unal
PublisherSpringer Verlag
Pages19-27
Number of pages9
ISBN (Print)9783319467191
DOIs
StatePublished - 2016
Externally publishedYes
Event1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: Oct 21 2016Oct 21 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9900 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
Country/TerritoryGreece
CityAthens
Period10/21/1610/21/16

Keywords

  • Cortical gyri and sulci
  • Functional dynamics
  • Spatial overlap pattern
  • Task-based fMRI

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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