TY - JOUR
T1 - Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts
AU - Diamond, Michael P.
AU - Saed, Ghassan
PY - 2007/3
Y1 - 2007/3
N2 - To determine the levels of peroxisome proliferators-activated receptors (PPARs) in normal and adhesion fibroblasts, we utilized real-time reverse transcription-polymerase chain reaction to measure messenger RNA (mRNA) levels in fibroblasts from normal peritoneum and adhesions from five patients in both the presence or absence of dichloroacetic acid (DCA) and a cyclooxygenase-2 (COX-2) inhibitor, NS-398. Peroxisome proliferators-activated receptor α, PPARβ, PPARγ1, and PPARγ2 mRNA are all present in normal peritoneal and adhesion fibroblasts, and selectively rose in response to hypoxia and either DCA or NS-398.
AB - To determine the levels of peroxisome proliferators-activated receptors (PPARs) in normal and adhesion fibroblasts, we utilized real-time reverse transcription-polymerase chain reaction to measure messenger RNA (mRNA) levels in fibroblasts from normal peritoneum and adhesions from five patients in both the presence or absence of dichloroacetic acid (DCA) and a cyclooxygenase-2 (COX-2) inhibitor, NS-398. Peroxisome proliferators-activated receptor α, PPARβ, PPARγ1, and PPARγ2 mRNA are all present in normal peritoneal and adhesion fibroblasts, and selectively rose in response to hypoxia and either DCA or NS-398.
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U2 - 10.1016/j.fertnstert.2006.07.1513
DO - 10.1016/j.fertnstert.2006.07.1513
M3 - Article
C2 - 17156782
AN - SCOPUS:33847749541
SN - 0015-0282
VL - 87
SP - 706
EP - 709
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -