Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts

Michael P. Diamond, Ghassan Saed

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To determine the levels of peroxisome proliferators-activated receptors (PPARs) in normal and adhesion fibroblasts, we utilized real-time reverse transcription-polymerase chain reaction to measure messenger RNA (mRNA) levels in fibroblasts from normal peritoneum and adhesions from five patients in both the presence or absence of dichloroacetic acid (DCA) and a cyclooxygenase-2 (COX-2) inhibitor, NS-398. Peroxisome proliferators-activated receptor α, PPARβ, PPARγ1, and PPARγ2 mRNA are all present in normal peritoneal and adhesion fibroblasts, and selectively rose in response to hypoxia and either DCA or NS-398.

Original languageEnglish (US)
Pages (from-to)706-709
Number of pages4
JournalFertility and sterility
Volume87
Issue number3
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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